157 results about "Ethylene glycol ester" patented technology

The invention discloses a method for preparing regenerated flame-retardant high-shrinkage polyester by a methanol alcoholysis method, and belongs to the technical field of polyester. The method comprises the following steps: (a) mixing the waste polyester fabric with methanol, and carrying out catalytic depolymerization to obtain a regenerated DMT mixed solution; (b) carrying out impurity separation and methanol recovery treatment on the regenerated DMT mixed solution, and then carrying out cooling crystallization, centrifugal drying and rectification purification treatment to obtain pure DMT; (c) carrying out transesterification on pure DMT, ethylene glycol, a transesterification catalyst and a DEG inhibitor; (d) after the ester exchange reaction, adding CEPPA-EG and IPA-EG for copolymerization; adding a polymerization catalyst, a stabilizer and an antioxidant for polymerization reaction to obtain a modified polyester melt; and (e) granulating and drying to obtain the slices. The regenerated polyester prepared by the method has multiple functions of flame retardance, high boiling water shrinkage, low-temperature dyeing and the like, and is suitable for the fields of high-end clothing, automotive trim, electronic packaging materials and the like.

The invention relates to the field of polyester, and discloses a method for continuously producing 1, 4-cyclohexanedimethanol by taking waste polyester as a raw material. Comprising the following steps: 1) mixing waste polyester with ethylene glycol, and performing alcoholysis under the action of an alcoholysis catalyst to obtain alcoholysis liquid containing diethylene glycol terephthalate; 2) performing primary hydrogenation on the alcoholysis solution under the catalysis of a hydrogenation catalyst A to obtain a reaction solution containing 1, 4-cyclohexane dioctyl phthalate diglycol ester; 3) performing secondary hydrogenation on the reaction liquid under the catalysis of a hydrogenation catalyst B to obtain a reaction liquid containing 1, 4-cyclohexanedimethanol; and 4) carrying out gas-liquid separation and rectification on the reaction liquid to obtain ethylene glycol and 1, 4-cyclohexanedimethanol. According to the method, the CHDM is produced by taking the waste polyester as the raw material, the method is simple in production process flow, and continuous production can be realized; through optimization of the catalyst and the process, high PET conversion rate, high CHDM selectivity, high CHDM yield and low production cost can be realized under relatively mild reaction conditions.

The invention relates to a preparation method and system of high-molecular-weight polyethylene glycol oxalate, and the preparation method comprises the following steps: adding oxalic acid diester, ethylene glycol and a first catalyst, and carrying out transesterification to obtain an ester; adding a second catalyst, and carrying out a pre-polycondensation reaction on the esterified product to obtain a glycol oxalate oligomer; polymerizing the ethylene glycol oxalate oligomer, and carrying out final polymerization reaction to obtain polyethylene glycol oxalate; the molar ratio of the oxalic acid diester to the ethylene glycol is (1.05-1.3): 1. Compared with the prior art, by controlling excessive oxalic acid diester in the raw material ratio, namely controlling the molar ratio of oxalic acid diester to ethylene glycol to be greater than 1, the reaction rate of ethylene glycol is improved, self-polycondensation of ethylene glycol is prevented, further increase of molecular weight is facilitated, and meanwhile, the thermal performance of the product is improved.

The invention relates to the field of PVC, and particularly discloses low-odor PVC artificial leather which comprises a surface layer, a surface layer, a middle layer and base cloth, raw materials of the surface layer and the middle layer comprise polyvinyl chloride prepared through suspension polymerization, an acrylonitrile-butadiene copolymer, octyl amyl glycol dibenzoate and polypropylene intercalated sepiolite, and the artificial leather has low odor and high strength.

The invention relates to a mud-resistant slump-retaining polycarboxylic acid water reducer and a preparation method thereof. The polycarboxylic acid water reducer is prepared from the following raw materials: 80-100 parts of polyether macromonomer; 1-2 parts of a rigid unsaturated monomer; 1-2 parts of a crosslinking monomer; 2-3 parts of an unsaturated sulfonic acid monomer; 10 to 15 parts of unsaturated acid; 0.5-2 parts of an oxidizing agent; 0.5-2 parts of a reducing agent; and 1-2 parts of a chain transfer agent. According to the invention, ethylene glycol monovinyl ether polyoxyethylene ether is adopted as a polyether monomer, a cross-linking monomer itaconic acid polyethylene glycol ester is introduced to form a cross-linked network-shaped molecular structure, and rigid structures such as (4-vinyl phenyl) trimethoxysilane are introduced, so that friction layer adsorption of clay is avoided, adsorption sites on the surface of the clay are reduced, and the adhesion of the clay is improved; the competitive adsorption effect of clay on the polycarboxylate superplasticizer is weakened, and the mud resistance and the slump loss resistance are greatly improved.

The invention provides a composite material porous bone repair scaffold as well as a preparation method and application thereof. The composite material porous bone repair scaffold is prepared from the following raw materials: a bone repair organic material, a bone repair inorganic material and poly (citric acid-1, 8-octylene glycol / ethylene glycol) ester particles. The biodegradable poly (citric acid-1, 8-octylene glycol / ethylene glycol) ester particles are added into the bone repair organic material and the bone repair inorganic material, so that the degradation rate of the bone repair scaffold can be regulated and controlled, and the degradation rate of the composite material is matched with the new bone regeneration rate; moreover, the bone repair scaffold has good biocompatibility and high osteogenic activity, the mechanical property of the bone repair scaffold can be improved, the mechanical behavior of natural bones can be simulated, and the stability of the scaffold can be improved.

The invention provides a fluoride-free weather-resistant polyester film and a preparation method thereof, and relates to the technical field of polyester films, the fluoride-free weather-resistant polyester film comprises the following components by weight: 70-90 parts of a semi-dull polyethylene glycol terephthalate high-viscosity slice; 8 to 28 parts of weather-resistant master batch; the weather-resistant master batch is obtained by modifying titanium dioxide through a silane coupling agent to form a silicon-titanium core-shell material and then carrying out solid-phase polycondensation on the silicon-titanium core-shell material and a polyester raw material. According to the fluoride-free weather-resistant polyester film provided by the invention, the weather-resistant master batch is prepared by introducing a silicon-titanium core-shell material formed by modifying titanium dioxide with a silane coupling agent into PET polyester and then carrying out solid-phase polycondensation on the silicon-titanium core-shell material and the polyester raw material, so that the production cost is reduced by utilizing the synergistic effect of all the components, and meanwhile, the fluorine-free weather-resistant polyester film has the advantages that the fluorine-free weather-resistant polyester film is prepared; the prepared fluorine-free weather-resistant polyester film has excellent hydrolysis resistance and ultraviolet resistance, and the weather resistance of the fluorine-free weather-resistant polyester film is remarkably improved.

The invention discloses a titanium-containing composition, a preparation method thereof and a polyester catalyst, and relates to the technical field of polyester catalysts, and the titanium-containing composition comprises reaction products of the following components: a titanium compound, a solvent, hydroxycarboxylic acid and / or amino acid. The titanium-containing composition is obtained by mixing and reacting the titanium compound, the solvent, the hydroxycarboxylic acid and / or the amino acid, the solvent adopts ethylene glycol ester, the flash point is high, the reaction activity with titanium is low, the preparation process is very smooth, meanwhile, the performance change of polyester is not caused when the titanium-containing composition is used for polyester, and the technical effect is good.

Disclosed in the present invention are a preparation method for a brain-targeting agomelatine nasal spray micelle and use thereof, which belong to the technical field of pharmaceutical formulations. According to the present invention, an injectable pharmaceutical excipient polyethylene glycol (15)-hydroxystearate (HS15) is taken as a carrier material, HS15 and agomelatine are dissolved in an organic solvent, and the resulting solution is subjected to rotary evaporation under reduced pressure to form a uniform film, which, upon hydration, forms an agomelatine micelle solution capable of being sprayed nasally for treating depression and insomnia. According to the present invention, the problem of low oral bioavailability of agomelatine due to poor solubility, serious first pass effect of hepar, difficulty in penetrating a blood-brain barrier, etc., is solved. The micelle structure constructed in the present invention is quickly delivered into the brain after nasal administration, and it is stable in cerebrospinal fluid and can achieve slow release of the drug, thereby improving the intracerebral bioavailability of the drug and achieving high brain targeting property and low systemic toxic and side effects. The micelle structure has good clinical application value and market prospects.

The invention relates to the technical field of water reducing agents, and discloses a slow-release polycarboxylic acid water reducing agent and a preparation method thereof.The slow-release polycarboxylic acid water reducing agent is prepared by adding polyoxyethylene ether, acrylic acid, hydroxyethyl acrylate, a propylene glycol methyl ether acetate chain transfer agent, monoethylene glycol phthalate, hydrogen peroxide, alkenylated silane and water into a stirrer, stirring, adding an initiator, and stirring to obtain a mixture; and finally, obtaining the slow-release polycarboxylic acid water reducer. Quaternary ammonium salt in the slow-release polycarboxylate superplasticizer increases the dispersity to cement particles, so that the surfaces of the cement particles are slightly positively charged, the fluidity of cement paste is increased, the strength of concrete is improved, and silane contained in the slow-release polycarboxylate superplasticizer can deeply permeate into capillary pore walls of the concrete and chemically react with hydrated cement, so that the strength of the concrete is improved. The silane-modified polycarboxylic acid water reducing agent has the advantages that a polysiloxane interpenetrating network structure is formed, the durability of concrete is improved, the content and substitution degree of silane are increased by a hyperbranched structure in the silane-modified polycarboxylic acid water reducing agent, the silane is hydrolyzed firstly in the hydrolysis process of the water reducing agent, and a good slow-release effect is achieved.

The invention provides a dental resin mixture, dental resin, a preparation method of the dental resin, a color difference uniformity evaluation method and a dental restoration. The dental resin mixture comprises inorganic particles, a polymerizable monomer and an initiator, wherein the particle size of the inorganic particles is 0.1-6 [mu] m, and the polymerizable monomer comprises triethylene glycol dimethacrylate and urethane dimethacrylate in a mass ratio of (1-4): (6-10). The invention provides the dental resin and the dental prosthesis which have the advantages that the chromatic aberration among all local areas is small, and the overall color uniformity of the product is better.

The application discloses a high viscosity-reducing polycarboxylic water reducing agent for ultra-high performance concrete and a preparation method thereof, and comprises the following steps: adding a metered amount of deionized water into a reaction container, and then adding a methyl allyl polyoxyethylene ether, sodium methallyl sulfonate, an alkyl acrylate, and styrene into the reaction container, stirring, and heating; adding a metered amount of hydrogen peroxide, and simultaneously dropping a mixed aqueous solution of acrylic acid AA and methoxy polyethylene glycol methacrylate MAA-MPEG and a mixed aqueous solution of mercaptoacetic acid and ascorbic acid; and after dropping, keeping warm. The prepared polycarboxylic water reducing agent can improve the dispersibility of the polycarboxylic water reducing agent, reduce the hydrophilicity of the whole polycarboxylic molecule, and obviously reduce the viscosity of concrete; under the premise that the concrete has good workability, the viscosity of high-grade concrete can be obviously reduced; the polycarboxylic water reducing agent has good adaptability to different types of cement, avoids the need to seek different types and structures of water reducing agents for different types of cement, and is beneficial to practical engineering application.

Cosmetic cleansing composition comprising surfactants The present invention relates to a cosmetic composition comprising, in a cosmetically acceptable medium: an aqueous phase, at least one amphoteric surfactant chosen from betaines, at least one linear α-olefin sulfonate, at least one ethylene glycol ester, and at least one crosslinked anionic acrylic polymer. Figure for abstract: none

The present invention provides a novel means for degrading PEF. Provided is a method for degrading polyethylene furanoate that includes causing an enzyme comprising a polypeptide which has an amino acid sequence having at least 90% identity with the amino acid sequence of SEQ ID NO: 1 and has one or more amino acid substitutions selected from the group consisting of H129W, F208S, A172C, and A209C to act on polyethylene furanoate.

The invention discloses an ophthalmic micro-emulsion preparation of tacrolimus, an ophthalmic in-situ gel preparation of tacrolimus as well as a preparation method and application of the ophthalmic micro-emulsion preparation and the ophthalmic in-situ gel preparation of tacrolimus. The tacrolimus eye micro-emulsion preparation comprises tacrolimus, a solubilizer and water, and the solubilizer comprises stearic acid polyethylene glycol ester and caprylic / capric acid polyethylene glycol glyceride. The tacrolimus ophthalmic in-situ gel preparation is prepared from tacrolimus, a solubilizer, a gel matrix and water. The tacrolimus ophthalmic microemulsion preparation and the tacrolimus ophthalmic in-situ gel preparation both can improve the drug loading capacity of tacrolimus, so that the effective drug amount acting on an affected part is improved; according to the tacrolimus eye microemulsion preparation, the solubility of tacrolimus can be remarkably improved, and eye medicine absorption can be promoted; according to the tacrolimus ophthalmic in-situ gel preparation, the retention time of eyes can be prolonged, and the bioavailability can be effectively improved.

Provided is a heat-shrinkable polyester film that not only has a high heat shrinkage in the main shrinkage direction, but also has a good heat shrinkability of recycled PET resin even when recycled together with used beverage PET bottles. A heat-shrinkable polyester film containing, in 100 mol% of a dicarboxylic acid component, 95 mol% or more and 100 mol% or less of a dicarboxylic acid, 0 mol% or more and 5 mol% of isophthalic acid, and containing, in 100 mol% of all ester units, 85 mol% or more and 98 mol% or less of terephthalic acid ethylene glycol ester units, and containing, in 100 mol% of a polyol component, 2 mol% or more and 15 mol% or less of diethylene glycol, has a prescribed hot water heat shrinkage, and has a melting peak temperature, a crystallization exotherm, and a melting exotherm determined by melting the film after melting and quenching using a differential scanning calorimeter (DSC), and then re-warming, within prescribed ranges.

The present application provides a plasticizer composition which does not color the obtained molded body and has excellent plasticizing properties. Specifically, a plasticizer composition consisting of diethylene glycol dibenzoate and 1,2-propanediol dibenzoate, the mass ratio of the diethylene glycol dibenzoate to the 1,2-propanediol dibenzoate being in the range of diethylene glycol dibenzoate:1,2-propanediol dibenzoate = 50:50 to 80:20.

The present invention provides an oral taxane pharmaceutical composition, which comprises a taxane drug and an excipient, wherein the excipient comprises a surfactant mixture, and the surfactant mixture is composed of Tween 80 and 15-hydroxystearate polyethylene glycol. The present invention significantly improves the solubility of taxane drugs (such as paclitaxel) through the synergistic solubilization effect of Tween 80 and 15-hydroxystearate polyethylene glycol, and the obtained preparation forms small particles after dilution, and can maintain the solution clear and transparent for more than 2 hours, solving the problem of rapid crystal precipitation and unfavorable absorption of the prior art preparation after dilution. The oral paclitaxel pharmaceutical composition of the present invention is combined with a P-glycoprotein inhibitor, and the oral bioavailability is significantly improved.

The application belongs to the technical field of waste PET recycling, and discloses a preparation method of an antibacterial polyurethane adhesive based on waste PET alcoholysis products. The method comprises the following steps: mixing 15-30 parts by weight of diisocyanate, 30-80 parts by weight of polyester polyol, 1-5 parts by weight of waste PET alcoholysis product terephthalic acid diethylene glycol ester and 0.3-0.7 parts by weight of a catalyst, reacting at 80-100 DEG C for 1-2 hours, cooling to 60-80 DEG C, adding 5-15 parts by weight of a chain extender, and reacting; in the reaction process, a diluent is added to obtain a hydroxyl-terminated polyurethane prepolymer; cooling to 40-55 DEG C, uniformly mixing 5-15 parts by weight of a blocked isocyanate curing agent and 40-80 parts by weight of a CS@Ag dispersion liquid to obtain the antibacterial polyurethane adhesive. The method is simple, realizes waste PET recycling, and improves the antibacterial performance and bonding performance of the polyurethane adhesive.

This invention provides a continuous method for preparing vitamin E succinate polyethylene glycol ester (TPGS). It uses a strongly acidic cation exchange resin (such as the Amberlyst series) or a perfluorosulfonic acid resin (such as the Nafion series) as a heterogeneous catalyst, which is packed in a fixed bed to catalyze the esterification reaction between vitamin E succinate and polyethylene glycol. This method achieves precise proportioning of reactants, instantaneous mixing, isothermal reaction, and online dehydration, reducing the reaction time from several hours required by existing batch methods to tens of minutes. It allows for long-term stable use, requires no complex post-processing, and produces products with high yield, good purity, and light color. The preparation method of this invention solves the problems of difficult catalyst recovery, excessive waste, low efficiency, and unstable product quality in existing methods, making it particularly suitable for large-scale, continuous, and green production of TPGS.

The invention relates to the technical field of heat-conducting silica gel, in particular to a heat-conducting silica gel composition and a heat-conducting silica gel preparation method. The high-temperature-resistant silicone rubber is prepared from the following components in parts by weight: 32 to 48 parts of vinyl silicone oil, 28 to 32 parts of nano aluminum nitride, 18 to 22 parts of expanded graphite microchips, 0.8 to 1.8 parts of gamma-aminopropyltriethoxysilane, 4.8 to 7.0 parts of hydrogen-containing silicone oil, 0.8 to 1.2 parts of hindered phenol antioxidant 1010 and 0.2 to 0.4 part of fatty acid polyethylene glycol ester. The particle sizes of the nano aluminum nitride and the expanded graphite microchips are precisely regulated and controlled, the nano aluminum nitride and the expanded graphite microchips synergistically construct a multi-layer heat conduction network, and the nano aluminum nitride effectively promotes heat conduction on the microscopic level by means of the high crystallinity and low interface thermal resistance of the nano aluminum nitride; and the expanded graphite microchips construct a heat conduction path on a macroscopic level by using a layered stacking structure of the expanded graphite microchips. The synergistic effect greatly reduces the interface thermal resistance in the heat transfer process.

The application relates to the technical field of high-temperature-resistant pipeline production, in particular to a multi-end-feeding double-screw extrusion pipeline and a preparation method of high-temperature-resistant polyethylene glycol adipate. The pipeline comprises a corrosion-resistant layer, a pipeline layer and a heat-insulating layer; the corrosion-resistant layer is made of vinyl ester resin, the vinyl ester resin is sprayed on the inner surface of the pipeline layer; the pipeline layer is made of high-temperature-resistant polyethylene glycol adipate, the particles are softened at high temperature, and the pipeline layer is formed by extrusion through a mold; the heat-insulating layer is made of ceramic fiber felt, the outer surface of the pipeline layer is uniformly brushed with a high-temperature adhesive binder, and the ceramic fiber felt is adhered to the outer surface of the pipeline layer. Carbon nanotubes are uniformly grafted on polyethylene glycol adipate to form a uniform heat-conducting net, the high-heat-resistance of polyether ether ketone is used to improve the heat-resistance of polyethylene glycol adipate, and the heat of a locally overheated position is guided to the surroundings through the heat-conducting net, so that decomposition caused by excessively high temperature is avoided. On the basis of improving the heat-resistance of the pipeline, the ability of the pipeline to resist uneven heat is improved.

The application belongs to the field of air filtration, and specifically discloses a kind of water and oil removal air filtration material and its preparation method, the preparation method is to mix and react octadecyl methacrylate, isobutyl methacrylate, acrylic acid, ethylene glycol ester and styrene for a preset time to form modified methacrylic acid resin, then the first fiber short filament is prepared by using modified methacrylic acid resin;The second fiber short filament is prepared by using polyacrylate resin;Glass wool, the first fiber short filament and the second fiber short filament are mixed to prepare to obtain water and oil removal air filtration material.The application can achieve the effect of water and oil removal while maintaining efficient filtration of solid particles in the air, greatly prolonging the service life of the air filtration material, reducing the filter replacement cost and manual work intensity.

The present application relates to a kind of anti-mud slump type polycarboxylic water reducer and its preparation method, the polycarboxylic water reducer preparation raw material includes: polyether macromonomer 80~100 parts;Rigid unsaturated monomer 1~2 parts;Crosslinking monomer 1~2 parts;Unsaturated sulfonic acid monomer 2~3 parts;Unsaturated acid 10~15 parts;Oxidant 0.5~2 parts;Reducing agent 0.5~2 parts;And chain transfer agent 1~2 parts.The present application uses ethylene glycol monovinyl ether polyoxyethylene ether as polyether monomer, introduces crosslinking monomer itaconic acid polyethylene glycol ester, forms crosslinked molecular structure, and introduces (4- vinylphenyl) trimethoxysilane and other rigid structure, avoids clay's wipe layer adsorption, reduces clay surface adsorption site, weakens the competitive adsorption effect of clay to polycarboxylic water reducer, greatly improves anti-mud performance and slump performance.

The present application relates to a kind of special cleaning solution for oil stain cleaning in the processing of aluminum alloy parts, which replaces hydrocarbon cleaning solution.The method of the present application is as follows: long-chain alkyl glycoside (APG) and oleic acid polyethylene glycol ester (PEG) with good biodegradability are used as detergent, low molecular weight acrylic acid-acrylamide copolymer is compounded with phytic acid as corrosion inhibitor, triethanolamine, sodium tripolyphosphate, hydroxyethylidene diphosphonic acid (HTPE) and other washing aids are used as washing aids, and antioxidants, defoamers and other aids are added, to produce aluminum alloy parts special cleaning solution by composite process.The cleaning solution has good washing performance, very low corrosivity, good biodegradability and other advantages, and can completely replace the currently used hydrocarbon cleaning solution in production.

The invention belongs to the technical field of conductive materials and rubber products, and particularly relates to maleopimaric acid macrogol ester modified titanium carbide, a preparation method and application thereof, conductive rubber and a preparation method thereof. According to the preparation method, maleopimaric acid macrogol ester is used for modifying titanium carbide nanoparticles, and maleopimaric acid macrogol ester modified titanium carbide is obtained. Carboxyl and hydroxyl of maleopimaric acid macrogol ester are stably combined with hydroxyl on the surface of titanium carbide, agglomeration of maleopimaric acid macrogol ester is effectively relieved, compatibility of maleopimaric acid macrogol ester with a rubber matrix is enhanced, the composite conductive filler is evenly dispersed in rubber, the conductivity of the prepared conductive rubber is remarkably improved, and the service life of the conductive rubber is prolonged. Meanwhile, the tensile strength, bending stability and other mechanical properties are excellent, and the material is suitable for the fields of electromagnetic shielding, flexible electronics and the like.

The invention relates to the technical field of medicines, and provides a semeglutide coated tablet and a preparation method thereof. The chip-coated sheet comprises a chip core layer and a shell layer, the tablet core layer comprises a first absorption enhancer; the shell layer comprises a second absorption enhancer; the first absorption enhancer and the second absorption enhancer are selected from the group consisting of sodium 8-(2-hydroxybenzamido) caprylate, Tween 80, lauryl sodium sulfate, sodium caprate, polyglycerol-3 diisostearate, oleic acid, lauric acid, sodium deoxycholate, sodium cholate, polyoxyethylene (35) castor oil, PEG-vitamin E succinate, PEG-vitamin D3 succinate and pluronic. The invention relates to a preservative which is prepared from the following raw materials: polyethylene glycol, a methoxy polyethylene glycol-polycaprolactone copolymer, sucrose fatty acid ester, 15-hydroxystearic acid polyethylene glycol ester and caprylic / capric acid polyethylene glycol glyceride. The coated tablet provided by the invention adopts a double-layer structure consisting of the tablet core layer and the shell layer, so that the bioavailability of the preparation can be remarkably improved, the oral dosage can be hopefully and greatly reduced, and the medication cost is reduced.

The invention discloses silver-coated copper powder and a preparation method and application thereof, and relates to the technical field of metal materials. The preparation method of the silver-coated copper powder comprises the following steps: preparing a dispersion liquid of copper powder, an amphiphilic block copolymer, vitamin E succinic acid polyethylene glycol ester, a reducing agent and a complexing agent, adding a soluble silver ion solution into the dispersion liquid, and reacting to obtain the silver-coated copper powder. The mass ratio of the amphiphilic block copolymer to the vitamin E succinic acid polyethylene glycol ester is 1: (0.8-4.5); the adding rate of the soluble silver ions is 0.01 g / min to 0.1 g / min. According to the preparation method, the silver-coated copper powder with good oxidation resistance and low silver content can be prepared.

The invention relates to a wastewater treatment device and process in the production process of polyethylene glycol lactate in the technical field of wastewater treatment and purification in the production process of polyethylene glycol lactate, and the wastewater treatment device comprises a water pollution prevention and control environment treatment pipe, a rotating rod, a first movable plate, a second movable plate and a plurality of stirring rods, an adjusting part in sliding connection with the end of the rotating rod is used for adjusting the distance between the first movable plate and the second movable plate, a stirring ring is movably inserted into the edge of the second movable plate through an elastic part, the stirring rod moves in the stirring ring, and a sliding rod connected with the adjusting part is in sliding fit with the middle of the second movable plate. The first movable plate and the second movable plate are driven to move away from each other or close to each other, meanwhile, a stirring ring and a stirring rod do circular motion and diffusion-contraction motion in the wastewater treatment pipe, the multi-dimensional and multi-layer stirring mode greatly improves the mixing efficiency of wastewater and neutralized substances, full proceeding of a neutralization reaction is promoted, and the wastewater treatment efficiency is improved. Therefore, the wastewater is effectively purified.

The invention discloses a brain-targeted nasal-spray amphotericin B phospholipid complex and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the brain-targeted nasal-spray amphotericin B phospholipid complex is prepared by adopting a film dispersion method, and the preparation method comprises the following steps: dissolving 15-hydroxystearic acid polyethylene glycol ester, phospholipid, cholesterol, amphotericin B and optional other auxiliary components in a solvent, removing the solvent until a film is formed, and drying to obtain the brain-targeted nasal-spray amphotericin B phospholipid complex. And carrying out hydration dispersion to obtain the amphotericin B-loaded phospholipid complex. According to the amphotericin B sodium deoxycholate injection, the problems that the traditional amphotericin B sodium deoxycholate injection is high in renal toxicity, the intrathecal injection is poor in solubility, and low in bioavailability and patient compliance, large in side effect and the like due to the fact that the traditional amphotericin B sodium deoxycholate injection is difficult to penetrate through a blood brain After nasal administration, the drug is quickly delivered into the brain, so that the slow release of the drug is realized, the intracerebral bioavailability of the drug is improved, high brain targeting and low systemic toxic and side effects are realized, and good clinical application value and market prospect are achieved.