The invention relates to a system for road surface slope detection and automatic adjustment of a wheelchair. The system comprises a wheelchair body and a control system, and is characterized in that the wheelchair body comprises a fixing frame, front wheels, rear wheels, a seat back, a foot pedal, hydraulic rods and damping spring supporting rods, and the control system comprises a motor, a hydraulic pump, a storage battery, a controller box and a front wheel drive motor; and the controller box is internally provided with a gyroscope, an accelerometer sensor and a controller main board. The system for road surface slope detection and automatic adjustment of the wheelchair mainly realizes that 1, through an accelerometer, the gyroscope detects the heeling condition of a road surface on which the wheelchair travels; 2, the wheelchair is automatically adjusted to be level according to the detected road surface condition to improve the comfort and safety of the ride; 3, according to the safety envelope of the wheelchair and the slope condition of the road surface, the traveling speed and the turning speed of the wheelchair are automatically adjusted; 4, when a slope exceeds the safe power of the wheelchair motor, the wheelchair is automatically stopped, the motor is protected, and a safety accident is avoided; and 5, through a speaker arranged in the wheelchair, the status of the wheelchair is automatically broadcasted to assist a user in driving.