30results about How to "Easy to realize industrial scale-up production" patented technology

The invention discloses a high-dispersity composition of low-dose drugs and a preparation method of the high-dispersity composition, aiming to solve the problem that existing preparation methods for the low-dose drugs cannot meet requirements on content uniformity and influences of parameter change amplification in the production process on physicochemical properties of the low-dose drugs are remarkable. The high-dispersity composition and the preparation method thereof have the advantages that the low-dose drugs are prepared by the twin-screw extrusion technology for the first time; Vitamin Danalogue drugs, glucocorticoid drugs, antipsychotics, antipyretic and analgesic drugs and other low-dose drugs are screened as research objects; preparation of solid preparations through a twin-screwextruder is studied deeply; the content uniformity meets requirements of the pharmacopeia.

The invention discloses a Cu-Zn-based catalyst used in a reverse water gas shift reaction for catalyzing CO2 hydrogenation conversion for producing CO, and a preparation method thereof and an application thereof. The Cu-Zn-based catalyst has a structural formula of CuaZnbMc. M is one or a combination of more than one selected from transition metal elements, alkali metal, alkaline earth metal or rare earth; a, b, and c are respectively molar fractions of Cu, Zn, and M; a is in the range of 40-60%, b is in the range of 30-60%, and c is in the range of 0-10%. The Cu-Zn-based catalyst provided by the invention has the advantages of low cost, simple preparation method, stable performance, and suitability for industrial large-scale production. Under low temperature, the catalyst has high reaction activity and high CO selectivity, and can be used in the reverse water gas shift reaction for synthesizing CO, such that CO2 emission rate can be reduced. The catalyst can also be used in coupling with a CO hydrogenation catalyst, such that products such as hydrocarbons low-carbon alcohols and high-carbon alcohols with high added values can be produced. The catalyst has good industrial application prospect.

The application discloses a preparation method of a surface-functionalized molybdenum carbide-carbon catalyst for a carbon dioxide hydrogenation reaction. The preparation method mainly comprises the following steps: firstly, using deionized water as a solvent, uniformly mixing sodium alginate with an ammonium molybdate solution, and then putting a mixed solution into a freeze drying oven for carrying out freeze drying; secondly, carrying out high-temperature roasting in an inert atmosphere to obtain porous graphite carbon-inlaid high-dispersibility molybdenum carbide; thirdly, mechanically lapping the prepared porous graphite carbon-inlaid high-dispersibility molybdenum carbide and urea, putting a lapped material into a muffle furnace, and carrying out annealing treatment to obtain the surface-functionalized molybdenum carbide-carbon catalyst. The catalyst prepared by the preparation method has the characteristics of large specific surface area, abundant pore structures and high dispersibility, and shows good catalytic activity and selectivity in the carbon dioxide hydrogenation reaction.

The invention discloses a microalgae composite living bait for fish seedlings and a production method thereof. The microalgae composite living bait is composed of microalgae liquid mixed according to the number of cells after the following microalgae species are cultivated: Chaetoceros mourii 10%~15%, Phaeodactylum tricornutum 15%~20%, Isochrysis globosa 10%~15%, Haematococcus pluvialis 10%~15%, Chlorella pyrenoidosa 30% ~35% and Pavlova 15%~20%, and the total density is 1.2×105~5.8×105 cells / mL. The production method is as follows: (1) use the photobioreactor to culture the microalgae and algae species separately, and obtain the microalgae liquid with a culture density of 1.1×109~5.6×1010 cells / mL; (2) the microalgae liquid The microalgae composite living bait is formulated according to the ratio of the number of cells, and the microalgae composite living bait with a total density of 1.2×105-5.8×105 cells / mL is obtained. In the present application, a variety of microalgae cells are made into compound living bait, which has balanced nutrition, can improve the survival rate of fish seedlings, and reduce the incidence of the disease.

The invention discloses a pre-lithium negative electrode material, a preparation method thereof, a pre-lithium negative electrode and a pre-lithium battery. The method comprises: 1) dispersing the negative electrode active material and metal lithium in an organic solvent to obtain a mixed solution; 2) using the mixed solution to carry out hydrothermal reaction to obtain a pre-lithium negative electrode material. The present invention utilizes a hydrothermal high-temperature and high-pressure environment to fully and evenly embed lithium metal into the structure of negative electrode active materials such as graphite materials, and has a good pre-lithium effect. Using the pre-lithium negative electrode material as a negative electrode active material for lithium-ion batteries can Effectively reduce the consumption of active lithium ions in the positive electrode and improve the electrochemical performance of the negative electrode, especially the first Coulombic efficiency.

The invention discloses a vitamin D analog preparation and a preparation method thereof. In order to solve the defects in the existing methods of preparing vitamin D analog drugs, which are difficult to meet the requirements of content uniformity, and the drug is easy to degrade and transform during the granulation process, the twin-screw extrusion technology is used for the first time to prepare vitamin D analogs. solid preparations. On the basis of extensively using various vitamin D analogues as model drugs and in-depth research on the preparation process of their solid preparations, alfacalcidol, idecalcitol or calcitriol are preferably processed through a twin-screw extruder. The solid preparation is prepared, and its content uniformity meets the requirements of the Pharmacopoeia, the stability of the drug is significantly improved, and the quality of the drug is greatly improved.

The invention provides a carbon dioxide hydrogenation synthesis formic acid catalyst and its preparation method and application, which belong to the technical field of catalyst synthesis and fine chemical industry. The Pd-based metal material catalyst provided by the present invention has the advantages of high dispersion of active metals, adjustable structure and properties on the atomic scale, and can realize the process of formic acid hydrogenation of carbon dioxide at normal temperature and pressure in terms of catalytic effect, and is expected to solve the problem of heterogeneous catalysts. The problem of low efficiency of catalytic conversion of carbon dioxide to formic acid under mild conditions provides a successful example for the capture and conversion of carbon dioxide at normal temperature and pressure, and the preparation method adopted in the present invention is simple and the production cost is low, so it has good practical application value.

The invention discloses a method for replenishing lithium in a lithium ion battery through a positive electrode. The method includes: 1) On both sides of the positive electrode current collector, the positive electrode slurry and the passivated lithium powder slurry are sequentially coated, dried, and rolled, and the positive electrode sheet material layer is sequentially formed on both sides of the surface of the positive electrode current collector and a passivated lithium layer to obtain a positive electrode precursor sheet; 2) process the positive electrode precursor sheet with a nitrogen gas flow, and the nitrogen reacts with the passivated lithium layer on the surface to form a positive electrode sheet; 3) assemble the positive electrode sheet The battery cell is assembled to obtain the battery, which is charged and discharged to realize the lithium replenishment of the battery. The pre-lithiated positive electrode material of the present invention can be produced under conventional process procedures and conventional temperature and humidity, and is easy to realize industrial scale-up production.

The invention provides a fenofibrate nano freeze-dried composition and a preparation method thereof. The preparation method comprises: preparing a nano-suspension, and freeze-drying the suspension. The preparation method provided by the present invention does not need to micronize the raw material drug in advance, which greatly reduces the energy consumption required for the experiment; the experimental conditions of the present invention are mild and controllable, the preparation time is short, and the production cycle is greatly shortened; there is no need to use high-pressure homogenization or Methods such as mechanical grinding have low requirements on equipment, low energy consumption, and are not prone to debris pollution; they are simple to operate, have good reproducibility, low cost, and are easy to realize industrial scale-up production. In the nanosuspension prepared by the invention, the particle size of the drug nanoparticles in the suspension is controlled at 150-350nm, the dissolution and release are fast, the gastrointestinal transmembrane transport capacity of fenofibrate is greatly improved, and the absorption of fenofibrate is promoted. .

The invention discloses a microalgae composite living bait for raising shellfish seedlings and a production method thereof. The microalgae composite living bait is composed of the following microalgae species cultured and mixed in proportion to the number of cells: Chaetoceros mourii 15%‑20%, Coccolithia 20%‑25%, Isochrysis globosa 5%‑10%, Haematococcus pluvialis 15%‑20%, Chlorella pyrenoidosa 25%‑ 30% and P. subcordiformis 10%‑15%, with a total density of 1×105‑5×105 cells / mL. The production method is as follows: (1) use a photobioreactor to culture the microalgae species separately to obtain a microalgae liquid with a culture density of 1×109-5×1010 cells / mL; (2) prepare the microalgae liquid The microalgae composite living bait is formulated according to the ratio of the number of cells, and the microalgae composite living bait with a total density of 1×105-5×105 cells / mL is obtained. In the present application, a variety of microalgae cells are made into compound living bait, which has balanced nutrition, can effectively improve the survival rate of shellfish seedlings, and reduce the incidence rate thereof.