The invention discloses a preparation method of a high-entropy oxide with good infrared radiation performance, wherein the preparation method comprises the steps: by taking any four of CuO, MnO2, Fe2O3, Cr2O3, Co3O4, TiO2, ZnO and MgO powder as raw materials, carrying out ball-milling mixing, drying and grinding, then carrying out high-temperature calcination in an air atmosphere, and cooling and grinding a product to obtain the high-entropy oxide with a spinel structure. The high-entropy oxide is prepared by combining a mechanical wet grinding method and a solid-phase synthesis method, metal elements can be guaranteed to be sufficiently and uniformly mixed, the method has the advantages of simple preparation technology, high repeatability, high production efficiency, suitability for industrial production and the like, and the prepared high-entropy oxide is single in phase, high in purity, small in particle size, uniform in element distribution, has high infrared emissivity and good thermal stability, and is used as an infrared radiation material in the field of infrared radiation heating and heat dissipation materials.