The invention provides an esterification catalyst, an esterification catalysis system and a method for preparation of the esterification catalyst and esterification catalyst reaction. The esterification catalyst is prepared from silica gel, and iron, zirconium, titanium, tin, scandium and sulfuric acid which are adsorbed on the silica gel; the mass percent of the iron, the zirconium, the titanium,the tin, the scandium and the sulfuric acid in the silica gel is respectively as follows: 9-30% of the iron, 0.009-0.015% of the zirconium, 9-30% of the titanium, 0.3-3% of the tin, 0.003-0.009% of the scandium and 59% of the sulfuric acid. The esterification catalysis system comprises a stock solution pool, a chemical filter pool, an adsorption area, a drying dehydration area, a roasting furnace, an esterification reaction pool, a deacidification oil tank and C-shaped macropore silica gel; the stock solution pool, the chemical filter pool, the adsorption area, the drying dehydration area, the roasting furnace, the esterification reaction pool and the deacidification oil tank are successively connected, and the C-shaped macropore silica gel is connected with the adsorption area. Accordingto the esterification catalyst, the esterification catalysis system and the method for the preparation of the esterification catalyst and the esterification catalyst reaction, the production cost ofbiodiesel is reduced, the sulfur content and acid value of a product achieve the purpose of meeting GB (V) diesel oil standard, the defect that traditional process causes environmental pollution easily is solved, and the esterification catalyst, the esterification catalysis system and the method for the preparation of the esterification catalyst and the esterification catalyst reaction make contributions to production of biodiesel, energy conservation, emission reduction and environmental protection.