The invention relates to a dedusting system for boiler flue gas desulfurization, in particular to a dedusting system for flue gas ammonia desulfurization. The invention also relates to a method for applying the dedusting system in an ammonia desulfurization system. The dedusting system comprises a desulfurizing tower, a slurry pump, a centrifugal machine, a clear liquid pool, a clear liquid pump, an electric control system and an evaporation concentration system, wherein the desulfurizing tower, the slurry pump, the centrifugal machine and the clear liquid pump positioned in the clear liquid pool are sequentially connected in series through a pipeline to form a closed loop, the centrifugal machine is connected with the electric control system, the centrifugal machine is also provided with a mud outlet, and the pipeline between the clear liquid pump and the desulfurizing tower is connected with the evaporation concentration system. By the dedusting system and an application method of the dedusting system, provided by the invention, the problems that in the existing ammonia wet-type desulfurization system, due to desulfurizing circulating solution contains the large ash content, a pump valve, a nozzle, a piping system and the like are seriously worn and blocked, and the like can be effectively solved, so that the ammonia wet-type desulfurization system can safely and stably operate, and the sulfur dioxide emission can reach the standard for a long time.