The invention provides a disease biomarker screening analysis method, a disease biomarker screening analysis platform, a server and a disease biomarker screening analysis system, wherein the disease biomarker screening analysis method comprises the following steps of: receiving an analysis instruction, wherein the analysis instruction includes sample screening conditions and analysis program parameters; obtaining clinical information of samples to be analyzed corresponding to the sample screening conditions according to the sample screening conditions, and obtaining relevant biological information according to the clinical information of the samples to be analyzed; sending the clinical information of the samples to be analyzed, the relevant biological information and the analysis program parameters to the server so as to analyze the clinical information of the samples to be analyzed and the relevant biological information; receiving an analysis result returned by the server, and performing significance inspection on the analysis result; and if the analysis result is non-significant, resetting screening conditions, and performing analysis again until the analysis result is significant. The method provides a platform associating the clinical information with genome information for the genome research aspect, and the great-sample-size gene verification experiment is facilitated.