4 results about "Nitrochlor" patented technology

The invention relates to the technical field of synthesis of organic compounds, and particularly discloses a synthesis process of paranitroaniline. The synthesis process comprises the following steps: (1) preparing strong ammonia water with the concentration of 38-42% by using an ammonia water preparation unit; (2) adding p-nitrochlorobenzene, stronger ammonia water and an auxiliary agent into the reaction kettle, and then carrying out heat preservation reaction for 14-16 hours under the conditions that the temperature is 150-170 DEG C and the pressure is 5.6-6.2 MPa; the auxiliary agent comprises modified cyclodextrin and trehalose; and (3) transferring the material in the reaction kettle into a water washing kettle after pressure relief, carrying out water washing stirring for 1-2 hours, and carrying out centrifugal separation on the material liquid after water washing to obtain p-nitroaniline. According to the synthesis process disclosed by the invention, the problem of balance between main reaction efficiency and side reaction inhibition is solved from a reaction mechanism level through compounding and synergy of the modified cyclodextrin and the trehalose, and finally, high yield and high purity in the paranitroaniline synthesis process are synchronously achieved.

The application relates to the technical field of organic compound synthesis, and particularly discloses a synthesis process of p-nitroaniline. The synthesis process of p-nitroaniline comprises the following steps: (1) preparing concentrated ammonia water with a concentration of 38%-42% by using an ammonia water preparation unit; (2) adding p-nitrochlorobenzene, concentrated ammonia water and an additive into a reaction kettle, and then carrying out heat preservation reaction under the condition of 150-170 DEG C and 5.6-6.2 MPa for 14-16 h; the additive comprises modified cyclodextrin and trehalose; (3) after pressure relief, the materials in the reaction kettle are transferred into a water washing kettle to carry out water washing and stirring for 1-2 h, and the material liquid after water washing is subjected to centrifugal separation to obtain p-nitroaniline. According to the synthesis process, the modified cyclodextrin and the trehalose are compounded and synergized, the balance problem of the main reaction efficiency and the side reaction inhibition is solved from the reaction mechanism level, and finally the high yield and the high purity in the synthesis process of p-nitroaniline are simultaneously achieved.

The embodiment of the invention relates to a method for synthesizing 2-nitro-6-chlorotoluene, and belongs to the technical field of organic synthesis. According to the method, 2-nitrotoluene and chlorine are used as raw materials, a tubular reactor or a common reactor is used as reaction equipment, chlorination is carried out at 10-50 DEG C under the condition of 180-400 nm ultraviolet irradiation, a mixture of 2-nitro-4-chlorotoluene and 2-nitro-6-chlorotoluene is obtained, rectification separation and purification are carried out, and 2-nitro-6-chlorotoluene is obtained. The method has the advantages of cheap and easily available raw materials, simple reaction operation, simple post-treatment, greenness, environmental protection, small pollution generated in the production process, realization of continuous production, reuse of unreacted raw materials, and substantial reduction of the cost.

This invention belongs to the field of pharmaceutical synthesis technology, specifically relating to a method for preparing chloroprocaine hydrochloride and its intermediates, and their applications. The invention uses 2-chloro-4-nitrobenzoic acid and N,N-diethylethanolamine as starting materials, and prepares nitrochlorocaine via sulfuric acid-catalyzed esterification. Nitrochlorocaine is then reduced with thiourea dioxide to obtain crude chloroprocaine. The crude chloroprocaine is then salted in hydrochloric acid and ethanol, crystallized, and dried to obtain the final product, chloroprocaine hydrochloride. This method features low cost, high product quality, high yield, simple process, high production capacity, environmental friendliness, and suitability for industrial production, thus possessing significant industrialization value.