The invention relates to the technical field of river prawn culture, and particularly discloses a growth-promotion anti-dissolution feed for river prawn culture. The feed is prepared from, by weight,40-60 parts of fish meal, 20-30 parts of glutinous rice flour, 10-15 parts of bean cakes, 6-8 parts of pork livers, 4-8 parts of yeast, 4-8 parts of fish oil, 4-6 parts of lecithin, 0.4-0.8 part of microelements, 0.8-1.2 parts of mixed vitamins, 6-12 parts of fructo-oligose, 4-8 parts of bentonite, 4-8 parts of sodium alga acid, 40-50 parts of film coating materials and 6-10 parts of gelatin. Thedefects in the prior art are overcome, carboxymethyl chitosan, sodium alga acid and hydroxy propyl cellulose are selected as the film coating material according to the proper ratio, the feed has the suitable water resistance, the phenomena that the feed is dissolved prematurely or hard to soften in water, and prawn feed is impeded are avoided, meanwhile, yeast and lecithin are added, normal shelling of river prawn can be ensured, growth is accelerated, feed digestion of river prawn is promoted, nutrient intake is increased, social benefits are obvious, and the feed is suitable for being popularized.