The invention discloses PVC (polyvinyl chloride) edge seal adhesive, made from, by weight, 38-48% of deionized water, 0.8-2% of an anionic emulsifier, 0.1-0.2% of a reactive emulsifier, 0.1-0.2% of abuffer agent, 2.5-4.5% of a stabilizer, 1.5-3.5% of a crosslinking agent, 0.2-0.5% of an initiator, 20-28% of an acrylic monomer, 20-30% of vinyl acetate, 0.5-1% of an internal plasticization monomer,3-10% of modified tackifying resin emulsion, 0.05-0.1% of a wetting agent, and 0.1-0.3% of a film-forming aid. In addition, the invention also discloses a preparation method of the PVC edge seal adhesive. The PVC edge seal adhesive is convenient to use, can cure at normal temperature, has high adhesive strength and good aging resistance, is free of organic solvents and formaldehydes and is nontoxic and environmentally friendly.