6 results about "Glycosyl acceptor" patented technology

The application discloses a kind of high stereoselectivity of alpha-xylopyranoside bond construction method, belongs to the technical field of sugar chemistry.The application uses full benzyl protected xylose trichloroacetimidate as glycosyl donor, by screening catalytic system, donor / acceptor ratio, additive type and molecular sieve type, optimize with trimethyl iodine silane as activating agent, triphenylphosphine oxide as additive high alpha-stereoselectivity glycosylation method.The method is mild in reaction condition, easy to operate, realizes the high stereoselectivity construction of 1,2-cis xylopyranoside bond without the action of participating group.Moreover, the method can be suitable for a variety of xylose donors with different protecting groups and a variety of glycosyl acceptors, to provide an effective means for efficient construction of a variety of alpha-xyloside and arabinoxylan modified by arabian mycin.

Described herein are novel methods of preparing sphingosines and glycosylated sphingosines. A method of preparing a glycosylated sphingosine as described herein includes an efficient, four-step route for synthesizing lactosylsphingosine (LacboSph) from Garner's aldehyde. Also described herein is a cost-effective method of synthesizing a variety of glycosylated sphingosines, sphingosines and glycosyl acceptors, including both the d18:1 and d20:1 D-erythro-sphingosines and the d18:1 and d20:1 D-erythro-sphingosine glycosyl acceptors, from xylose.

The invention belongs to the field of chemical synthesis, and relates to glycosyl thioether with oxime functional groups and a preparation method and application thereof. According to the invention, glycosyl thioether with oxime functional groups is prepared, the glycosyl thioether is used as a glycosyl free radical donor, a styrene compound is used as a glycosyl acceptor substrate, and a method for synthesizing alkyl C-glycoside through visible light catalysis is established and is used for synthesizing a series of C-glycoside compounds. The oxime-bonded glycosyl thioether prepared by the invention is stable in property, the preparation method has the advantages of simplicity, convenience, high yield, wide applicable saccharide range and the like, and the oxime-bonded glycosyl thioether is applied to synthesis of carbon glycoside and has the advantages of simplicity, wide substrate application range, including various drugs and polypeptides and the like. Therefore, the glycosyl thioether provides a new thought for development of complex glycoconjugates and drugs, and further promotes industrial development of carbon glycoside medicines.

The application discloses a fisetin-4'-O-alpha-D-glucopyranoside for resisting lung cancer and a preparation method and application thereof, and the preparation method comprises the following steps: taking sucrose as a glycosyl donor, taking fisetin as a glycosyl acceptor, and performing an enzymatic transglycosylation reaction under the catalysis of sucrose phosphorylase to direct the glucose group generated by decomposing the sucrose to be transferred to a hydroxyl group at a C4' position of the fisetin, so that a target product is obtained; and the sucrose phosphorylase is derived from Bifidobacterium adolescentis. The application retains the original core biological activities of the fisetin, such as antioxidation and anti-inflammation, provides high-quality raw materials for the application of the fisetin in the fields of innovative drug development for resisting lung cancer and preparation of medical intermediates, and expands the clinical transformation potential of fisetin compounds.

The invention discloses a synthesis method and application of beta-adamantane galactose thioglycoside and galactosamine derivatives thereof, and the method comprises the following steps: feeding at 0-5 DEG C, dissolving a compound 1 and adamantane in anhydrous dichloromethane, adding titanium tetrachloride and cobalt dichloride to carry out concerted catalysis, heating to 20-30 DEG C, reacting for 10-14 hours, filtering, washing, and drying to obtain the beta-adamantane galactose thioglycoside. And quenching, extracting, drying, concentrating under reduced pressure and purifying by column chromatography to obtain a compound 2. The method has the advantages of easily available raw materials, convenient operation, small peculiar smell, mild and easily controllable reaction conditions and high synthesis yield, and can realize industrial amplification; the established glycosylation application system adapts to eight kinds of different glycosyl receptors, the product yield is stable, the process universality is high, and the glycosylation application system can be widely applied to synthesis of disaccharide and oligosaccharide and glycosylation modification and synthesis of complex galactose (amine)-containing drug molecules for resisting infection, tumor and virus and the like, and has a wide application prospect. The method has remarkable industrial application value and wide market prospect in the fields of sugar chemistry, drug synthesis and biological medicine, and completely meets the industrial production requirements.

The application discloses an anti-inflammatory and anti-oxidative gallic acid glycoside as well as a preparation method and application thereof. The preparation method comprises the following steps: taking sucrose as a glucosyl donor, taking gallic acid as a glucosyl acceptor, and performing an enzymatic reaction under the catalysis of sucrose phosphorylase to transfer a glucosyl generated by the decomposition of sucrose to a C4 hydroxyl group of the gallic acid to obtain the gallic acid glycoside; and the sucrose phosphorylase is derived from Bifidobacterium adolescentis. In the application, sucrose is taken as a glucosyl donor, gallic acid is taken as a receptor, and a glucosyl generated by the hydrolysis of sucrose is accurately transferred to a C4 hydroxyl group of the gallic acid through a high-efficiency transglycosylation reaction, so that the conversion rate of a target product is significantly improved, and core technical support is provided for large-scale preparation.