The invention discloses an epoxy-structure adhesive for prefabrication and splicing of a bridge segment. The epoxy-structure adhesive is prepared by mixing a component A and a component B, and duringconstruction, the components A and B are mixed according to the mixing ratio of 3:1, wherein the component A comprises bisphenol A epoxy resin, hydrogenated bisphenol A epoxy resin, novolac epoxy resin, a diluent, a flexibilizer, fumed silicon dioxide, silica powder, short fibers, a silane coupling agent, an ultraviolet light absorber and a defoaming agent, and the component B comprises phenolic-aldehyde-modified polyamide-amine, autocatalytic modified alicyclic amine, cardanol polyacetals amine and a high-activity silane coupling agent. According to the epoxy-structure adhesive, through compounding between the bisphenol A epoxy resin, the hydrogenated bisphenol A epoxy resin and the novolac epoxy resin and the diluent, the flexibilizer and the like, and addition of the short fibers, a filler and the like, the epoxy-structure adhesive has the advantages that the operable time is long, the strength increase is quick, and the adhesive can adapt to different operation environment temperatures, and has good resistance to damp-heat aging and long service life; the epoxy-structure adhesive is more suitable for being applied to prefabrication and splicing construction of the bridge segment.