The invention relates to the technical field of cosmetics. The invention discloses quantum-content process mild, nourishing and softening shampoo and a preparation method thereof. The shampoo containscarbomer, an anionic surfactant, piroctone ethanolamine salt, a cationic conditioner, cocamidopropyl betaine, cocamidomethyl MEA, olive oil PEG-8 esters, zinc pyrithione, a chelating agent, polydimethylsiloxane alcohol, C12-13 alkanol polyether-15, cetrimonium chloride, dodecylbenzene sulfonic acid TEA salt, a preservative, essence and water. The preparation method comprises the following steps:heating and mixing carbomer and water, and adding the anionic surfactant; then sequentially adding piroxone ethanolamine salt and a cationic conditioner, cooling, and then adding cocamidopropyl betaine; and sequentially adding the remaining components in the shampoo to obtain the shampoo. The shampoo has high softening and cleaning functions, and the combing performance and refreshing feeling of hair are improved.