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40results about How to "Physiological function is good" patented technology

Liquid fruit vegetables preparation method

InactiveCN1602704AIncrease contentRich in active ingredients of edible fungiFruit and vegetables preservationVegetable JuicesSoluble dietary fiber
The invention discloses a kind of production of liquid fruit and vegetables. The way express the fresh vegetables juice by physics methods, then put the draft in the liquid edible fungus to ferment, forming fermentation liquor, then homogenate the ferment, filtrating the effective constituent, to gain the fruit and vegetables' ferment juice, mix these two kinds of juice, forming the clarified juice having much nourish of fruit and vegetables, as a kind of production for general using. The technique exploit the way on the stage, apply a new way for people's supplying fruit and vegetables.
Owner:HUAZHONG UNIV OF SCI & TECH

Method for extracting ponkan dietary fibers through extrusion modification and enzymolysis coupling

The invention belongs to the technical field of deep processing methods of subsidiary agricultural products, and particularly relates to a method for extracting extracting ponkan dietary fibers through extrusion modification and enzymolysis coupling. The method comprises the steps of by taking ponkan hide trimmings as raw material, carrying out hot ironing, drying, grinding, mixing and extrusion modification, adding water for dispersion, adjusting the pH, adding compound enzyme for enzymolysis, carrying out enzyme deactivation and centrifugation to obtain filtrate and precipitate, carrying out concentration, alcohol precipitation, alcohol washing, centrifugation and drying on the filtrate to obtain water-soluble dietary fibers, and carrying water washing, centrifugation and drying on the precipitate to obtain insoluble dietary fibers. According to the method for extracting extracting ponkan dietary fibers through extrusion modification and enzymolysis coupling, the content of the dietary fibers in the ponkan hide trimmings is improved, the functionality of the ponkan hide trimmings is strengthened, meanwhile, a new path is provided for the comprehensive utilization of the ponkan by-products, the deep processing of the subsidiary agricultural products is realized and the resource waste is decreased.
Owner:CHINA AGRI UNIV

Fructus cannabis protein biscuit and preparation method thereof

The invention provides a fructus cannabis protein biscuit and a preparation method thereof. The fructus cannabis protein biscuit comprises the following components in parts by weight: 100-150 parts of low-gluten flour, 10-20 parts of fructus cannabis protein powder, 10-30 parts of green banana whole meal, 2-8 parts of ultrafine powder of grape seed, 10-12 parts of custard flour, 40-60 parts of butter, 10-15 parts of white granulated sugar, 15-25 parts of whole egg liquid, 0.3-0.8 part of salt, 0.3-0.6 part of sodium bicarbonate, 1-2 parts of baking powder, 5-15 parts of whole milk powder and 80-120 parts of water. The fructus cannabis protein biscuit has the beneficial effects that firstly, the fructus cannabis protein component is beneficial for human health, and is easy to digest and absorb after being separated and extracted; secondly, the compound green banana whole meal has the physiological effects of enhancing the prevention and cure of bowel diseases, reducing the blood sugar and the like; the grape seed has the physiological effects of resisting oxidation, increasing the immunity and the like; thirdly, the biscuit disclosed by the invention has the characteristics of high protein, high cellulose and low fat, and the physiological effects of the fructus cannabis protein can be well maintained; fourthly, the biscuit also has the functions of promoting gastrointestinal motility, promoting digestion, adjusting the gastroenteric environment, resisting oxidation, reducing blood fat, reducing blood pressure, reducing cholesterol, resisting fatigue and the like.
Owner:AGRI PROD PROCESSING INST GUANGXI ACADEMY OF AGRI SCI

Processing method of sugar-free fruit and vegetable crushed dried pork

The invention relates to a processing method of sugar-free fruit and vegetable crushed dried pork. The existing crushed dried pork can not meet the requirements of special people groups, namely patients with diabetes, old people, children and the like. The processing method comprises the following process steps: selecting materials, processing raw material meat, boiling meat blocks, blending the materials, frying pork flakes, rubbing the pork flakes, picking the pork flakes and packaging; 40-60kg of the raw material meat, 1-1.5kg of common salt, 9-12kg of fructooligosaccharides, 0.04-0.07kg of I+G, 0.6-0.8kg of monosodium glutamate, 0.002-0.004kg of monascus color, 0.2-0.6kg of sodium erythorbate, 4-8kg of fruit and vegetable powder and 5-20kg of broth are selected as raw materials; the broth is boiled, and the common salt, the fructooligosaccharides, the I+G, the monosodium glutamate, the monascus color, the sodium erythorbate and a meat embryo loose body are added; and stir-frying is performed twice, then the fruit and vegetable powder is added into the crushed dried pork, and a finished product is further obtained by rubbing the pork flakes, picking the pork flakes and packaging. The crushed dried pork produced by the processing method is comfortable in taste, unique in flavor and particularly suitable for the patients with the diabetes, the old people and the children for taking.
Owner:ZHEJIANG QINGLIAN FOOD

Inotropic antibodies and therapeutic uses thereof

Antibodies binding to sites on the α-subunit (Na++K+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In particular, antibodies binding to the RSATEEEPPNDD (SEQ ID NO: 1) or DVEDSYGQQWTYEQR (SEQ ID NO: 2) peptides (or isoforms / derivatives thereof) of the α-subunit of the (Na++K+)-ATPase, have been found to be highly inotropic. Both the antibodies and the peptides are important for the treatment of human heart failure and other contractile disorders.
Owner:UNIV OF MARYLAND BALTIMORE

Pre-mixed feed capable of enhancing reproductive performance of cow

The present invention relates to a milk cow feed, in particular to a premix which can increase the reproductive performance of the milk cow. The technic proposal of the premix is that ferrous amino acid, zincous amino acid, manganic amino acid, cupreous amino acid, selenic amino acid and calcinol are mixed with the zeolite powder to form a microelement semi-finished product; the vitamin A, vitamin D, vitamin E and dihydropyridine are mixed with the corn powder to form a vitamin semi-finished product which is used as raw material; and then the final product of the present invention is made by evenly mixing the microelement semi-finished product and the vitamin semi-finished product with the zeolite in a proportion of 3:2:5. The present invention is suitable for milk cow in yeld period, breeding cow and milk cow in primary matting without milk period. The additive rate is 1 percent of the concentrate supplement material. The reproductive performance of the milk cow feeding with the present invention is improved, the oestrus rate is improved by 5 percent to 15 percent, the pregnancy rate is improved by 11 percent and the one-off matting pregnancy rate is improved by 6 percent to 8 percent.
Owner:BEIJING SANYUAN HEFENG ANIMAL HUSBANDRY

Sophora flower bud drink

The invention belongs to the field of traditional Chinese medicine healthcare, and particularly relates to a sophora flower bud drink with physiological effects of preventing and treating cardiovascular and cerebrovascular diseases and the like. The sophora flower bud drink is prepared from 1wt%-5wt% of a sophora flower bud medicine combination extracting solution, 8wt%-15wt% of a flavouring agent, 1wt%-5wt% of aromatic water and the balance being water, wherein the flavouring agent at least comprises sugar and acid, and the content of acid is 1 / 12 to 1 / 8 of that of sugar; the ratio of the aromatic water to the extracting solution is equal to 0.8 to 1.0. The effective and stable drink with the physiological effects of preventing and treating cardiovascular and cerebrovascular diseases can be obtained, and the drink is free from the pungent odour of medicinal herbs, proper in sourness and sweetness, good in taste, free from astringent taste and bitter taste, good in storage stability, and suitable for drinking every day, and has improved fragrance. The invention further relates to a preparation method of the sophora flower bud drink. The method is simple and practicable, and is suitable for industrialized production.
Owner:重庆万源佳药业有限公司

Fermented foods containing biidobacterium

InactiveCN1384711AFresh fermented yogurt-like flavorEasy to handleMilk preparationBifidobacteriumFood flavorIngested food
Production of fermented foods having sufficient stability and Excellent flavor. These bifidobacterium-containing fermented foods are obtained by fermenting a medium containing soybean milk as a main component using bifidobacteria selected from the group consisting of Bifidobacterium catenosa and Bifidobacterium pseudostrenoid.
Owner:YAKULT HONSHA KK

Compositions And Methods For Regulating Cardiac Performance

The present invention relates to cardiac performance, in particular to regulating cardiac performance via recombinant troponin I (TnI) protein and nucleic acids encoding recombinant TnI. The present invention provides nucleic acids encoding gain of function TnI proteins (e.g., cTnlA164H), vectors containing such nucleic acids, host cells containing such vectors, transgenic animals carrying a gain of function TnI protein (e.g., a cTnlA164H transgene), and therapeutic agents (e.g., comprising recombinant TnI, TnI analogues, synthetic TnI, or the like) or agents for gene therapy of heart failure or disease for research and therapeutic uses.
Owner:RGT UNIV OF MICHIGAN

Low-allergenic milk protein powder and preparation method thereof

The present invention relates to low-allergenic milk protein powder and a preparation method thereof. The preparation method comprises the following steps: dispersing milk protein powder in pure waterand conducting stirring until the milk protein powder is fully dissolved to obtain a first milk protein solution; adding an anthocyanin extract into the first milk protein solution and conducting stirring at room temperature in a dark place to obtain a second milk protein solution; and conducting drying after the second milk protein solution is concentrated through an ultrafiltration membrane toprepare the low-allergenic milk protein powder. Thus, a non-covalent interaction between the anthocyanins and protein changes spatial conformation of the milk protein, thereby reducing antigenicity; besides, the preparation method is simple, easy to realize industrial production, does not produce bitter peptides, also does not cause loss of protein processing functional properties; and at the sametime, the anthocyanins have good physiological activity, and can endow dairy products with higher nutritional value and good sensory quality.
Owner:ZHEJIANG LIZIYUAN FOOD CO LTD

Functional food containing Dendrobium officinale and longan and preparation method thereof

InactiveCN105077051ANeutralizing heatGreat tasteFood preparationWater solubleSugar
The present invention discloses a functional food containing Dendrobium officinale and longan. The functional food comprises the following raw materials by weight: 1-25 parts of Dendrobium officinale, 40-60 parts of dried longan, 5-25 parts of medlar, 1-10 parts of American ginseng, 1-5 parts of Ganoderma lucidum and 1-5 parts of ginger. The preparation method of the above functional food is as below: respectively conducting aqueous extraction, filtering and concentration on each raw material to obtain extracts; mixing the extracts, then concentrating; adding a right amount of water-soluble starch and sugar substances; and preparing granules, electuary, paste or beverage products by different processes. The functional food containing Dendrobium officinale and longan has the health care functions of nourishing yin, invigorating qi, enhancing immunity and building up body, and is convenient for eating, good in taste, and suitable for all types of people.
Owner:MINNAN NORMAL UNIV

Ascorbic acid derivatives, their preparation methods, intermediates and uses in cosmetics

A kind of ascorbic acid derivates 3-O-glyco-L-ascorbic acid, their preparation methods, intermediates and uses in cosmetics. The derivates used as vitamin C precursors have better physiological effect than 2-O-α-D-glucopyranosyl ascorbic acid (AA-2G) and are more stable. Present compounds can be used in many fields, such as in cosmetics, pharmaceuticals, foodstuffs and livestock feed, and especially as whitening agents in cosmetics. The preparation method involves protecting the 5,6-dihydroxyl of ascorbic acid, then coupling with 1-haloacylglycosyl, obtaining the intermediate 3-O-(acylglycosyl)-(5,6-O-isopropylidine)-L-ascorbic acid, removing the isopropylidine and acyl from the intermediates, thereby obtaining the target substance.
Owner:NANJING ZHONGSHI CHEM

Marine bioactive peptide capable of effectively relieving skin sunburn, and preparation method and application of marine bioactive peptide

The invention discloses a marine bioactive peptide capable of effectively relieving skin sunburn, and a preparation method and application of the marine bioactive peptide. The marine bioactive peptide is small in molecular weight, good in skin compatibility and capable of remarkably reducing apoptosis and necrosis of cells irradiated by ultraviolet rays and reducing true dermatitis exudation and elastic fibre degradation. The preparation method of the marine bioactive peptide comprises the following steps of: taking a soft part of a fresh marine shellfish, carrying out protease enzymolysis, ultrafiltration and sephadex separation, discarding the last elution single peak, respectively collecting or mixing other elution components, and performing freeze-drying to obtain the marine bioactive peptide. The method is simple, low in cost, green, environment-friendly, short in production cycle and suitable for industrial production; the prepared active peptide has the effects of preventing and repairing skin sunburn and can be applied to cosmetics and biomedical materials; the cosmetic dosage forms include cream, emulsion, gel, jelly, water aqua, mist spray and the like; and dosage forms of the biomedical material comprise lotion, solution, dressing (thin film, hydrocolloid, hydrogel, sponge and spray), ointment, injection and the like.
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI

Traditional Chinese medicine composition for treating acute attack of bronchial asthma and preparation method thereof

InactiveCN106075163AActive ingredient extractionFully extractedUnknown materialsRespiratory disorderPinelliaMuscle spasm
The invention discloses a traditional Chinese medicine composition for treating acute attack of bronchial asthma and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 50-60 parts of fresh rhizome of hirsute shiny bugleweed herb, 30-35 parts of fresh sweet stevia, 15-18 parts of perilla leaf, 15-18 parts of Chinese magnoliavine fruit, 15-18 parts of Chinese ephedra, 15-18 parts of bulbus fritillariae ussuriensis, 15-18 parts of areca seed, 15-18 parts of pulp of dark plum fruit, 15-18 parts of root of common hogfennel, 20-23 parts of ternate pinellia, 20-23 parts of pine pollen, 20-23 parts of tangerine peel, 20-23 parts of bitter apricot seed, 20-23 parts of common anemarrhena rhizome, 10-12 parts of gypsum, 20-23 parts of pulp of medicine terminalia fruit, 20-23 parts of longstamen onion bulb, 20-23 parts of bamboo shavings, 30-35 parts of black beans, 30-35 parts of barbary wolfberry fruit, 30-35 parts of bitter orange, 30-35 parts of dwarf lilyturf tuber, 30-35 parts of snakegourd fruit, 20-23 parts of ginkgo seed, 150-180 parts of processed honey and 30-35 parts of rice vinegar. The traditional Chinese medicine composition has the advantage that gypsum contained in the traditional Chinese medicine composition has the effects of relieving heat, diminishing inflammation and stopping pain and relieving spasm.
Owner:安徽天乾健食品科技有限公司

Production method and application of coix seed, red yeast rice and lotus leaf functional granulated tea

InactiveCN106035909APromote leachingThe taste is not rough but delicateTea substituesRed yeast riceBiotechnology
The invention discloses a production method and an application of coix seed, red yeast rice and lotus leaf functional granulated tea. The production method comprises the steps of monascus strain spore suspension preparation, coix seed boiling, cooling, red yeast rice mixing and fermenting, lotus leaf tea submicron powder preparation, granulation and gradient baking. The coix seed, red yeast rice and lotus leaf functional granulated tea product produced in the invention facilitates efficacy factor leaching and boiling drinking of the product, and the leaching rate and the leaching speed of effective components of the product are improved by 37.2% and 232.5% respectively; the product can be stirred in boiling powder to form a paste for direct eating, and avoids rough mouthfeel after entering the human oral cavity; and the product can be added to other foods as a functional food ingredient without influencing the quality of products, for example, the product can be added to steamed breads, noodles, cakes and beverages to exploit a series of healthy foods.
Owner:NANJING LONGZHUANG BIOTECH

Preparation method for wheat bran dietary fiber

The invention discloses a preparation method for wheat bran dietary fiber. According to the method, double modification of steam explosion treatment and lactobacillus fermentation is performed on wheat bran, and a post-treatment step is performed to obtain the dietary fiber; and insoluble dietary fiber and water-soluble dietary fiber can be obtained simultaneously. The extraction rate of the dietary fiber is increased, the composition and structure of the dietary fiber are changed, and the physiological activity of the dietary fiber is improved.
Owner:唐山市食品药品综合检验检测中心

Huai Mi drink

The invention belongs to the field of traditional Chinese medicine health care, and in particular relates to a Sophora japonica drink with physiological functions of preventing and treating cardiovascular and cerebrovascular diseases, which contains the following components (a), (b), (c) and (d), wherein: (a) 1 to 5% by weight of Sophora japonica medicinal composition extract; (b) 8 to 15% by weight of a flavoring agent, the flavoring agent at least including sugar and acid, and the amount of the acid is 1 / 1 of the sugar content 12 to 1 / 8; (c) is 1 to 5% by weight of aromatic water, and c / a=0.8 to 1.0; (d) is the remaining water. According to the present invention, a drink with good and stable physiological effects of preventing and treating cardiovascular and cerebrovascular diseases can be obtained. The drink has no irritating smell of Chinese medicinal herbs, is suitable for sweet and sour taste, has a good taste, has no astringency or bitterness, has improved taste, and can be stored Good stability, suitable for daily drinking. The invention also relates to a preparation method of Sophora japonica beverage, the method is simple and easy, and is suitable for factory production.
Owner:重庆万源佳药业有限公司

Sponge cake

An object of the present invention is to provide a sponge cake that does not become concave-shaped in the center even when it uses a fructooligosaccharide having physiological functions, such as decay resistance, the effect of promoting bifidobacterium growth, the effect of improving the metabolism of lipids such as cholesterol, the effect of regulating immunity, and the effect of inhibiting a rise in blood sugar level. According to the present invention, there is provided a sponge cake comprising a saccharide comprising a fructooligosaccharide, and a water-soluble polymer selected from the group consisting of collagen peptide, xanthan gum, and guar gum.
Owner:MEIJI CO LTD

Preparation method of liver clearing and eyesight improving grape wine

The invention discloses a preparation method of liver clearing and eyesight improving grape wine. According to the preparation method, cabernet sauvignon grape juice is mainly utilized as a raw material, and auxiliary materials of lotus root, water chestnut, prunella vulgaris petal, flos chrysanthemi indici, dried mulberry, fructus lycii and old ginger are also added. The grape wine prepared in the preparation method disclosed by the invention can nurse liver and kidneys, clear liver fire to achieve an eyesight improving effect at the same time and further has the effects of protecting liver, nourishing liver, expelling toxin and clearing heat. The raw materials of the preparation method of the grape wine disclosed by the invention are neutral in nature and sweet in taste; when the raw materials are mixed with grape wine broth, effects can be better given to play; thus, the prepared grape wine is mellower in taste, reduces bitterness of the Chinese herbal machine and can be more accepted by mass consumers.
Owner:苏州健乔食品科技有限公司

10-hydroxy-cis-12-octadecenoic acid alkyl ester and use thereof

The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to an alkyl ester of 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, or ester of 10-hydroxy-cis-12-octadecenoic acid with dihydric alkanol or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.
Owner:KYOTO UNIV +1

Marine biological medical material for repairing skin wounds as well as preparation method and application of marine biological medical material

The invention discloses a marine biological medical material for repairing skin wounds as well as a preparation method and application of the marine biological medical material. From a plurality of marine bioactive substances, preferably, marine fish skin collagen, carboxymethyl chitosan and alginate which are good in biocompatibility and easy to process and degrade are scientifically combined with platelet-derived growth factors PDGF-BB, and optimization is carried out, so that the marine collagen-based hydrogel is prepared. The material has the advantages of being high in porosity, high in swelling ratio, good in mechanical property, capable of controlling slow release of PDGF-BB, free of cytotoxicity and the like, cell adhesion, proliferation, migration and vascularization can be remarkably promoted, inflammatory response is effectively relieved, and scar hyperplasia is reduced. The biomedical material is wide in application range and convenient to use, can prevent bacterial infection without frequent replacement, and has remarkable effects of promoting regeneration and repair of burns, scalds, cutting wounds, traffic wounds, surgical wounds, war wounds, firearm wounds combined with seawater soaking wounds, diabetic ulcers, inflammatory ulcers, pressure ulcers and chronic refractory wounds.
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI

Health-care wine

The invention provides health-care wine. The health-care wine comprises the following raw materials in parts by weight: traditional Chinese medicine micro powder and wine in a ratio of 20-200g / L, wherein the traditional Chinese medicine micro powder is prepared from Ficus erecta Thunb. var., semen cuscutae, liquorice and the like and has grain size of 0.1-10mu m. The health-care wine conditions the balance among livers, spleens and kidneys, quenches thirst, disperses blood stasis, removes turbidity, relaxes muscles, stimulates blood circulation and dredges collaterals via Ficus erecta Thunb. var., semen cuscutae, bamboo leaves and the like, thus achieving the aim of reducing blood lipid.
Owner:孙健春

Atorvastatin amino acid and preparation method thereof

The invention relates to an atorvastatin amino acid and a preparation method thereof. Atorvastatin acid reacts with alkaline amino acid to obtain the compound. The preparation method comprises the following steps: (1) weighing the atorvastatin acid, and dissolving the atorvastatin acid into C1-C6 alcohol solvents, water or chlorinated hydrocarbon solvent to form a solution A; (2) weighing the alkaline amino acid, and dissolving the alkaline amino acid into C1-C6 alcohol solvents or water to form a solution B; and (3) adding the solution B into the solution A, enabling the mixed solution to beclear, separating out crystals from a mother solution, i.e., the atorvastatin amino acid. The atorvastatin amino acid prepared by the invention not only has the effect of treating hypercholesterolemia and combined hyperlipidemia, but also additionally has the functions of amino acid, for example, arginine has a protection function on liver, and therefore, the salt provided by the invention effectively makes up the defect that the known calcium salt, kali salt, sodium salt and the like have the side effect of damage to liver.
Owner:SHANGHAI KECHOW PHARMA

A marine biomedical material for skin wound repair and its preparation method and application

The invention discloses a marine biomedical material for repairing skin wounds and a preparation method and application thereof. From many marine biological actives, the preferred marine fish skin collagen, carboxymethyl chitosan, alginate with good biocompatibility, easy processing and degradation, and the platelet-derived growth factor PDGF-BB are scientifically combined and optimized for preparation made. The material has the advantages of high porosity, high swelling ratio, good mechanical properties, controlled release of PDGF-BB, and no cytotoxicity. It can significantly promote cell adhesion, proliferation, migration and angiogenesis, effectively reduce inflammation and reduce scarring. . The biomedical material has a wide range of applications, is easy to use, can prevent bacterial infection without frequent replacement, and is effective in promoting burns, scalds, cuts, traffic injuries, surgical injuries, war injuries, firearm injuries combined with seawater immersion injuries, diabetic ulcers, inflammation The regeneration and repair effect of chronic ulcers, pressure ulcers and chronic refractory wounds is remarkable.
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI

Preparation method for sunflower seed oligopeptide with high F value

The invention discloses a preparation method for sunflower seed oligopeptide with a high F value. According to the method, sunflower seed meal protein is used as a raw material, multienzyme combined hydrolysis technology is used for enzymatic hydrolysis so as to hydrolyze sunflower seed concentrated protein into polypeptide with aromatic amino acid as its end groups, the polypeptide is hydrolyzed into aromatic amino acid, free amino acid and oligopeptide by using a second enzyme, then desalination and removal of free amino acid and aromatic amino acid are carried out by using microfiltration and nanofiltration two-stage membrane so as to increase the proportion of the F value, and finally desalination, condensation and freeze drying are carried out to obtain sunflower seed oligopeptide with a high F value. The invention has the following technical effects: (1) reaction conditions are mild, and an obtained product has high activity; (2) a preparation method is clean and environment-friendly, produces no pollution and is in accordance with national policies relating to clean production; and (3) a prepared product has substantial physiological effects and is completely applicable to the industry of health products.
Owner:GUANGDONG FOOD IND INST

Liquid fruit vegetables preparation method

The invention discloses a kind of production of liquid fruit and vegetables. The way express the fresh vegetables juice by physics methods, then put the draft in the liquid edible fungus to ferment, forming fermentation liquor, then homogenate the ferment, filtrating the effective constituent, to gain the fruit and vegetables' ferment juice, mix these two kinds of juice, forming the clarified juice having much nourish of fruit and vegetables, as a kind of production for general using. The technique exploit the way on the stage, apply a new way for people's supplying fruit and vegetables.
Owner:HUAZHONG UNIV OF SCI & TECH

A kind of rosuvastatin amino acid salt and its preparation method and application

The invention relates to a rosuvastatin amino acid salt as well as a preparation method of the rosuvastatin amino acid salt. Such a compound, namely, amino acid salt, is prepared through the reaction between rosuvastatin acid and basic amino acid. The preparation method comprises the following steps of: (1) weighing rosuvastatin acid, and dissolving into C1-C6 alcohol solvents, water or a halohydrocarbon solution to obtain a solution A; (2) weighing basic amino acid, and dissolving into C1-C6 alcohol solvents or water to obtain a solution B; (3) adding the solution B to the solution A, stirring and remaining overnight, cooling the reaction liquid to reach room temperature, and then vaporizing and eliminating the solvents; (4) adding methanol, separating and filtering to remove excessive basic amino acid; and (5) concentrating, refluxing, cooling, filtering and drying to obtain the amino acid salt of the rosuvastatin. The rosuvastatin amino acid salt prepared by the preparation method not only has the effect of treating high cholesterol blood lipid and combined hyperlipidemia, and also gains the function of amino acid, thus the salt effectively fills in gaps due to the known side effects of hurt of calcium salt, sylvite and sodium salt and the like to the liver.
Owner:SHANGHAI KECHOW PHARMA
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