The invention relates to a pharmaceutical reaction device, particularly to a flowing water source type temperature-controllable pharmaceutical reaction device, which comprises a medicine reaction kettle, a first phase-change heat exchanger, a second phase-change heat exchanger, an electronic expansion valve, a four-way reversing valve and an inverter compressor. According to the invention, under the working condition of refrigeration / heating, the second phase-change heat exchanger continuously releases / absorbs heat into the water tank, the position where flowing water with heat / cold is used isjudged according to the water temperature detected by the third temperature sensor and the fourth temperature sensor, and in the process, the efficiency that the first phase-change heat exchanger provides corresponding cold / heat for the medicine reaction kettle is improved, flowing water from the high-temperature / low-temperature water outlet pipe in the used water tank can be recycled in different process links such as a sterilization preheating link or a cooling precooling link and the like for medicine manufacturing according to actual requirements, gradient utilization of energy is achieved, energy is saved, and the environment is protected.