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This invention relates to the field of chemical analysis technology, specifically to a method for detecting oxidized condensed tannins in red wine. The test solution containing oxidized condensed tannins is divided into a treatment solution and a blank control solution. An acidic depolymerization reagent is used to depolymerize the treatment solution, yielding a depolymerized solution. Ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-MS / MS) is used to detect the depolymerized solution and the blank control solution separately, and the content of oxidized condensed tannins is calculated. The acidic depolymerization reagent includes menthol furan and hydrochloric acid, with the concentration of menthol furan being 15-25 mmol / L and the concentration of hydrochloric acid being 0.4-0.6 mol / L. This method is the first to achieve simultaneous qualitative and quantitative analysis of the constituent units of natural, quinone-oxidized, and acetaldehyde-oxidized condensed tannins. It has the advantages of being non-toxic and odorless, suitable for routine laboratory use, and provides an effective method for predicting the degree of oxidation and aging potential of wine.