The invention belongs to the technical field of Chinese medicinal compositions, in particular to a Chinese medicinal composition for removing toxins, and also relates to a preparation method of the composition.The traditional Chinese medicine composition comprises: A: a mixture of trichosanthin, glutinous rice, licorice; trichosanthin: glutinous rice: licorice = (4-8): (1-3): (1-3); B: medlar 15-30, scrophularia 15-30, clear midsummer 20-30, raw gypsum 50-150, gallbladder star 15-25, lily 10-25, rehmannia 30-50; C: astragalus 10-30, ginseng 10-30, atractylodes 15-35, Atractylodes 10-20, Gardenia 10-20, Scrophulariaceae 10-20, Qing Pinxia 10-15, Gypsum 30-50, Danan Star 10-20, Lily 10-20, Rehmannia 30-50, Angelica 10-100. The invention has the advantages of simple formula, less flavor of traditional Chinese medicine and low cost, and is favorable for lightening the burden of patients. As that curative effect is prominent, the treatment of the invention is mostly within 5 to 7 day, and the curative effect can be obvious.