The invention discloses a
linezolid preparation method.
Dichloromethane is taken as a
solvent, a
potassium bromide solution is added, cooling is carried out, (5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-
hydroxymethyl-2-oxazolidinone is added, a catalyst of a tetramethyl piperidinyloxyl
nitride oxide is added while stirring is carried out, a
sodium hypochlorite solution is added dropwise, after adding is carried out dropwise, reaction is carried out for 1-3 hours at the temperature of 0-10 DEG C,
dichloromethane is added for extraction, an organic phase is dried and filtered through
anhydrous sodium sulfate, and (5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-
formaldehyde-2-oxazolidinone is obtained after the
solvent is condensed. Methyl
alcohol is taken as a
solvent, the (5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-
formaldehyde-2-oxazolidinone is added and heated to 20-50 DEG C,
acetamide is slowly added, liquid-phase chromatogram track reaction is conducted, a reduction agent is directly added after the reaction is completed,
precipitation and filtering are carried out, and
linezolid is obtained. The method is moderate in reaction condition and
environmentally friendly, and can be used for industrial large-scale production.