The invention discloses an anti-aging aronia melanocarpa wine and a preparation method thereof, and relates to the technical field of wines. The wine is prepared from the following raw materials in parts by weight: 40 to 60 parts of aloe gel juice, 20 to 40 parts of radix polygoni multiflori powder, 400 to 500 parts of grapes, 100 to 200 parts of aronia melanocarpa, 30 to 40 parts of blueberries,4 to 6 parts of mulberries, 10 to 20 parts of Chinese wolfberry and 0.1 to 0.3 part of a preservative. According to the anti-aging aronia melanocarpa wine and a preparation method thereof, aloe has the health-care effects of sterilizing, diminishing inflammation, promoting the stomach, improving the immunity, detoxifying, resisting tumors, resisting radiation, preventing corrosion and insects, helping produce saliva and slake thirst, maintaining beauty and keeping young; polygonum multiflorum can tonify essence and blood, blacken beard and hair, strengthen muscles and bones and tonify liver and kidney; the synergistic effect of the two components can improve the body state of people and effectively enhance the body immune function, and the blueberries are matched to improve the sleep quality, relieve pressure, relax people, prevent cranial nerve aging and enhance brain power, so that a remarkable anti-aging effect is achieved, and the traditional Chinese medicine composition is commonin medicinal materials and low in production cost.