The present invention relates to a traditional Chinese medicine for treating leukoderma, psoriasis ichthyosis and refractory psoriasis. The medicine is a combination of an orally taken preparation, an externally applied medicine liquid and an externally applied ointment. The orally taken preparation is prepared from lithospermum, ephedra, ligusticum, Sorrel, Gardenia jasminoides Ellis, sulphur and bean curd; the externally applied medicine liquid comprises cortex lycii, burdock-seed fructus arctii, cimicifuga foetida, centipede, scorpion, Strychnos nuxvomica, gartersnake, mylabris, frog and Hydrargyri Oxydum Rubrum; and the externally applied ointment is prepared from black bean oil and potassium halide. The medicine provided by the invention employs the combination of orally taken Chinese medicine and externally applied Chinese medicine to expel evil, supports normal Qi and treat both symptoms and root causes, is suitable for various kinds of tinea, especially leukoderma, psoriasis and ichthyosis, and has the features of determined healing effect, short healing period and no recurrence. In addition, the medicine provided by the invention can also be used for treating malignant boil, sore, carbuncle, scabies and eczema.