The invention discloses a high-temperature-resistant titanium alloy plate. A titanium alloy plate material is prepared from the following components in percentage by weight: 0.5 to 1.2 percent of aluminum, 3 to 5 percent of silicon, 0.2 to 0.5 percent of iron, 1.2 to 1.8 percent of nickel, 0.1 to 0.2 percent of carbon and the balance of titanium. A preparation process of the titanium alloy plate comprises the following steps: 1, mixing all the raw materials according to the formula amounts, feeding the mixture into a vertical type induction heating furnace, controlling heating temperature at 1,400 to 1,450 DEG C for smelting, and performing ingoting to form a titanium alloy ingot; 2, performing hot rolling on the titanium alloy ingot prepared in the step 1 to prepare a titanium alloy plateblank; 3, performing thermal treatment on the titanium alloy plate blank prepared in the step 2; 4, performing alkaline pickling on the titanium alloy plate subjected to the thermal treatment in thestep 3 to remove a surface oxide film, and mechanically grinding the titanium alloy plate till the surface coarseness is 0.5 to 1 [mu]m, thereby obtaining the titanium alloy plate. The high-temperature-resistant titanium alloy plate is good in thermal stability and high-temperature creep resistance. The invention further discloses a method of annealing the titanium alloy plate.