The invention discloses a quick-acting blood enrichment nutri-gel pills and a preparation method and application thereof and relates to the technical field of blood enrichment preparations. The bloodenrichment nutri-gel pills use seven traditional Chinese medicinal materials of blood enrichment nutri-gel, polygonum multiflorum, glossy privet fruits, mulberries, eclipta, white paeony roots, astragali radix and rhizoma cibotii as the raw materials. The blood enrichment nutri-gel pills are obtained through extensive research and screening and the processes of pretreatment, freeze drying, ultrafine pulverization, extraction and concentration, auxiliary material processing, pill mold preparation and molding and packaging. The active ingredient content of the blood enrichment nutri-gel pills prepared by the process is high, and the pills basically have no toxic side effects and good taste under the premise that the safety and stability are ensured, are quick to act, enrich and nourish blood, nourish the liver and kidney, soothe the nerves, restore consciousness, have the good relief effect on leukopenia caused by tumor radiotherapy and chemotherapy, and significantly enhance the patients' immunity.