11 results about "Magnesium iodide" patented technology

The invention relates to the technical field of preparation of small molecule compound medicines, in particular to a preparation method of (S)-flurbiprofen. The method comprises the following steps: dropwise adding a tetrahydrofuran solution of 4-bromo-2-fluorobiphenyl into a mixture of tetrahydrofuran and magnesium, and reacting to generate a Grignard reagent; mixing tetrahydrofuran, (S)-vinyl chloride oxide and ferric acetylacetonate, dropwise adding the Grignard reagent, performing acidolysis ring opening, and performing methylation with methyl iodide and magnesium iodide to obtain an alpha-hydroxyl aromatic carboxylic acid derivative; and reacting with sodium chlorite, nitroxide free radicals and acetonitrile, and oxidizing to obtain the (S)-flurbiprofen. By introducing a chiral induction unit, effective transmission of chiral information is realized in a coupling stage, an original chiral center is not destroyed in a subsequent reaction, and a product is ensured to have a highly consistent configuration. According to the scheme, the technical problem that a method capable of remarkably improving the optical purity and yield of (S)-flurbiprofen is lacked in the prior art can be solved, and the method has good environmental friendliness and industrial application prospects.

The invention belongs to the technical field of organic chemical synthesis, and particularly relates to a synthetic method of deuterated toluene-D3, which comprises the following steps: reacting deuterated iodomethane with magnesium to obtain a Grignard reagent deuterated methyl magnesium iodide; and then carrying out coupling reaction on the deuterated methyl magnesium iodide and bromobenzene under the catalysis of a nickel metal catalyst to obtain the deuterated toluene-D3. The synthesis method solves the problems of many byproducts, high cost and low utilization rate of deuterated raw materials when the existing toluene synthesis process is used for preparing semideuterated toluene, realizes efficient synthesis of high-purity deuterated toluene-D3, greatly reduces the generation of polymethyl compounds, and is short in production period and simple in post-treatment.

This invention discloses a method for preparing high-compact lithium iron phosphate (LFP) cathode material and the prepared LFP cathode material. Using lithium, iron, phosphorus, and carbon sources as raw materials, the LFP cathode material is prepared via a high-temperature solid-state method. A flux is added to the raw materials, and the flux is selected from one or more of magnesium carbonate, magnesium iodide, and magnesium hydroxide. This invention uses magnesium-containing compounds such as magnesium carbonate, magnesium iodide, and magnesium hydroxide as fluxes, enabling the preparation of LFP cathode material under low-temperature sintering conditions. This significantly reduces energy consumption, effectively avoids the generation of magnetic foreign matter such as iron phosphate, reduces electron transport resistance, and promotes particle densification growth. The compacted density of the prepared LFP cathode material is not less than 2.467 g / cm³. 3 The resistivity is not higher than 32.5 Ω•cm.

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a preparation method of deuterated tert-butyl alcohol, which comprises the following steps: A, reacting deuterated iodomethane with magnesium under the protection of inert gas by using anhydrous butyl ether as a reaction solvent to generate deuterated methyl magnesium iodide; b, reacting deuterated methyl magnesium iodide with deuterated acetone to generate an intermediate product; and C, reacting the intermediate product with deuterated sulfuric acid, and further purifying to obtain the deuterated tert-butyl alcohol. Compared with a traditional method for preparing the deuterated tert-butyl alcohol by firstly synthesizing the tert-butyl alcohol-D9 and then performing hydrogen-deuterium exchange, the method has the advantages of high yield and simplicity in operation, and is suitable for large-scale production.

The present invention discloses a method for preparing methylboronic acid d3. The method comprises reacting methyl iodide d3 with magnesium shavings to produce methylmagnesium iodide d3, which is then reacted with trimethyl borate to produce dimethyl methylborate. The product is then quenched with acid for hydrolysis and purified to obtain methylboronic acid d3. The product prepared by the present invention has high purity, high yield, and high degree of deuteration.

The invention relates to a calcium iodide-based organic electrolyte, a secondary battery and a preparation method of the calcium iodide-based organic electrolyte, the electrolyte is composed of calcium salt, an organic solvent and an additive, the calcium salt is calcium iodide or a combination of calcium iodide and other calcium salt, the organic solvent is one or a combination of more of ether organic solvent, sulfone organic solvent, ester organic solvent, amide organic solvent, ionic liquid organic solvent and amine organic solvent; the additive is selected from one or more of lithium borohydride, sodium borohydride, potassium borohydride, zinc borohydride, magnesium borohydride, lithium iodide, sodium iodide, magnesium iodide, potassium iodide, tetraethyl ammonium borohydride, tetramethyl ammonium borohydride, benzyltriethyl ammonium borohydride and tetra-n-butylammonium borohydride. Compared with the prior art, the fluoride-free, thermodynamically stable and low-passivation-effect calcium iodide-based electrolyte provided by the invention can improve the interface property of a calcium metal negative electrode-electrolyte and increase the stability of the electrolyte, so that the cycle life of a calcium metal battery is prolonged, and the stability of the calcium metal battery is improved.

The invention relates to the field of the oil production industry, and more particularly to heavy well kill fluids containing at least one of the compounds: calcium bromide, barium bromide, magnesium bromide, strontium bromide, zinc bromide, calcium iodide, barium iodide, magnesium iodide, strontium iodide and zinc iodide, and to methods for producing same. The invention discloses a method which makes it possible to broaden the range of components that can be used to produce heavy kill fluids. The claimed method makes it possible to produce a heavy well kill fluid using accessible salt solutions, wherein the resulting fluid has the necessary properties for effectively killing wells. The claimed method includes mixing solutions of salts at a molar ratio of 0.5-1.3:2, evaporating the resulting mixed solution to a density of 1400-2650 kg / m3, cooling the evaporated solution to a temperature of less than 25°C to form a precipitate, and filtering the evaporated solution to obtain a filtrate in the form of a heavy well kill fluid.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of 2-(4-(cyclopropyl formyl) phenyl)-2-methyl tert-butyl propionate 13C. Comprising the following steps: introducing carbon dioxide (13C) into tetrahydrofuran and a reagent A at-80 DEG C to synthesize cyclopropanecarboxylic acid (13C), wherein the reagent A is cyclopropyl magnesium bromide and cyclopropyl magnesium iodide: adding the cyclopropanecarboxylic acid (13C), dichloromethane, dimethyl hydroxylamine hydrochloride and 4-dimethylaminopyridine into triethylamine at room temperature, and reacting at the temperature of-80 DEG C to obtain the cyclopropanecarboxylic acid (13C). The preparation method comprises the following steps: synthesizing N-methoxy-N-methyl cyclopropanecarboxamide-13C from 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride; the preparation method comprises the following steps: adding 2-(4-bromophenyl)-2-tert-butyl methyl propionate and tetrahydrofuran into a reaction kettle, dropwise adding an alkali solution at the temperature of-40 DEG C, and dropwise adding N-methoxy-N-methylcyclopropanecarboxamide-13C to synthesize 2-(4-(cyclopropanecarboxyl) phenyl)-2-tert-butyl methyl propionate-13C, thereby obtaining the 2-(4-(cyclopropanecarboxyl) phenyl)-2-tert-butyl methyl propionate-13C. The method is reasonable in route, low in cost, high in yield and easy to industrialize.

The invention discloses a method and device for generating a magnesium ion beam in an ion implanter, and relates to the technical field of semiconductor manufacturing, and the method comprises the following steps: heating a solid-state source containing magnesium iodide to form steam containing magnesium iodide; conveying the steam containing magnesium iodide into an ion source arc chamber; the steam entering the ion source arc chamber is ionized to form plasma containing Mg < + >; mg < + > in the plasma is led out to form a milliampere-level magnesium ion beam; the magnesium iodide-containing solid source is completely composed of magnesium iodide or a mixture of magnesium iodide and a magnesium simple substance. According to the method provided by the invention, milliampere-magnitude magnesium beams can be generated, and injection use can be met; the magnesium iodide and the magnesium elementary substance are mixed to be used as a solid-state source, so that the magnesium ion beam can be improved, the service time of the ion source is prolonged, and the maintenance frequency is reduced.

The invention relates to a method for co-producing chlorosilane and iodoethane. The method comprises the following steps: enabling tert-butyl dimethyl ethyoxyl silane (dimethyl vinyl ethyoxyl silane or tert-butyl diphenyl ethyoxyl silane) and thionyl chloride to enter a micro-channel reactor at the same time to react; rectifying the reaction liquid to obtain tert-butyl dimethyl chlorosilane (dimethyl vinyl chlorosilane or tert-butyl diphenyl chlorosilane) and diethyl sulfite; the method comprises the following steps: putting magnesium iodide into a reaction container, adding water to prepare a solution, starting stirring, and heating; slowly dropwise adding the byproduct diethyl sulfite; and after dropwise adding, reacting to obtain iodoethane.

The invention relates to a solid, analgesic dosage form for oral administration with abuse deterrent properties, said dosage form comprising: (a) one or more active ingredients having potential for abuse selected from the group consisting of Alfentanil, Benzhydrocodone, Buprenorphine, Butorphanol, Codeine, Dihydrocodeine, Fentanyl, Hydrocodone, hydrocodone bitartrate, Hydromorphone, Levorphanol tartrate, Meperidine hydrochloride, Methadone, Morphine, Normethadone, Opium, Oxycodone, Oxymorphone, Pentazocine, Tapentadol, Tramadol, TEV-90105, ELI-202, or pharmaceutically acceptable salts and solvates thereof; (b) magnesium salt selected from the group consisting of consisting of Magnesium acetate, Magnesium benzoate, Magnesium bromate, Magnesium bromide, Magnesium carbonate, Magnesium chlorate, Magnesium chloride, Magnesium chromate, Magnesium citrate, Magnesium fluoride, Magnesium fluorosilicate, Magnesium formate, Magnesium glycinate, magnesium hydroaspartate, Magnesium hydroxide, Magnesium iodate, Magnesium iodide, Magnesium lactate, Magnesium L-threonate, Magnesium Malate, Magnesium molybdate, Magnesium nitrate, Magnesium oxalate, Magnesium oxide, Magnesium perchlorate, Magnesium phosphate, Magnesium selenite, Magnesium sulfate, Magnesium sulfate heptahydrate, Magnesium sulfite, Magnesium thiosulfate or a combination thereof, c) piperine.