The invention relates to textiles, in particular to cotton polyester interwoven spandex core-spun elastic fabric. The cotton polyester interwoven spandex core-spun elastic fabric comprises cotton, polyester and spandex. Sixteen threads of cotton are woven in the warp direction, and 150D low-elasticity interlaced yarn and 70D spandex coated yarn are woven in the weft direction. The dyeing process includes the steps of fabric turnover, desizing, single-face singeing, oxygen bleaching, shaping, mercerizing, double dyeing of pad dyeing and dyeing in the same color and finishing, wherein a scouring and bleaching combined production line is adopted in the steps of scouring retreating and oxygen bleaching. The fabric is subjected to six-latticed countercurrent flattening washing prior to rolling pressure so as to control moisture content to be 45-55% and subjected to padding in oxygen-bleaching liquid for fabric bleaching; a scouring retreating and bleaching combined machine arranged in the scouring and bleaching combined production line comprises a desizing machine and an oxygen-bleaching machine, the desizing machine comprises a first desizing-machine washing section, a desizing-machine steaming box and a second desizing-machine washing section, the oxygen-bleaching machine comprises an oxygen-blenching-machine washing section, an oxygen-blenching-machine steaming box, a drying cylinder, a heat exchanger, a desizing-machine filter box, a desizing-machine return water pump, an oxygen-bleaching-machine filter box and an oxygen-bleaching-machine return water pump. The fabric is stable in size after being washed, needless of ironing and energy saving in production.