The invention discloses a device and a method for preparing stable microcluster water by use of an ultrasonic heating technology. The device comprises a water inlet pipe, a raw water pump, deionizing equipment, ultrasonic heating equipment and a water outlet pipe, wherein the water inlet pipe is sequentially connected with the raw water pump, the deionizing equipment, the ultrasonic heating equipment and the water outlet pipe; the deionizing equipment consists of an active carbon filter, a reverse osmosis membrane component and a mixed bed, and the active carbon filter is sequentially connected with the reverse osmosis membrane component and the mixed bed; the ultrasonic heating equipment consists of a first ultrasonic tank, a second ultrasonic tank, an ultrasonic heating tank, a heating bath device and a third ultrasonic tank, the first ultrasonic tank is sequentially connected with the second ultrasonic tank, the ultrasonic heating tank and the third ultrasonic tank, and the heating bath device is connected with the ultrasonic heating tank. According to the invention, the preparation method is simple, thd device can continuously operate, discharge volume is great, economy is good; and the prepared microcluster water has less cluster molecules, high in permeability, easy in absorption and good in stability since the properties of the prepared microcluster water can be kept for a long time.