The invention discloses a method for preparing fattening feed for river crab in Taihu Lake, the feed comprises the following components by weight percentage: 3-5% of peanut meal, 15-20% of domestic fish meal, 35-40% of soybean meal, 18-20% of wheat, 4-5% of rice bran, 10-15% of rapeseed meal, 2% of soya-bean oil and 4% of premix. The method comprises the following steps: 1)performing superfine grinding on peanut meal, domestic fish meal, soybean meal, wheat, rice bran and rapeseed meal, sending to a mixing warehouse of a mixer in order; 2)directly adding soya-bean oil and the premix in the mixing warehouse of the mixer; 3)turning on a mixer for stirring for 8-10 minutes to prepare a mixture, sending the mixture into a pelleting bin; 4)preparing the slaking particles by the mixture in the pelleting bin through a granulator under high temperature steam effect, sending the slaking particles to a stabilizer and cooling to normal temperature in a stable mode; and 5)grading for processing the cooled particles by a grading sieve, then sealing and packaging according to required weight. According to the invention, the preparation cost is low, the feed nutrition is comprehensive and safe, anaphase growth of the crab is fast, and crab cream can be greatly grown.