The present invention relates to a water-base fast-drying high gloss ambient crosslinking nail paint resin and a preparation method thereof. The composition components comprise n-butyl acrylate, n-butyl methacrylate, methyl methacrylate, styrene, methacrylic acid, diacetone acrylamide, adipic dihydrazide, ammonium persulfate, emulsifier OP-10, emulsifier sodium dodecyl sulfate, ammonia and deionized water. After the resin is prepared into water-base nail paint (also called nail polish), the content of volatile organic compounds is less than 20 gram per liter, the nail paint does not contain harmful substances, such as triphenyl, formaldehyde and the like, has no poison and no smell, is harmless to human bodies and has no pollution to the environment, short drying time, strong adhesion and water resistance, high brightness of the paint film, bright color and strong color retention, as the solid content of the resin is high, the paint film thickness of thin painting is guaranteed, the surface is full and smooth, and the resin is an environmental-friendly product which can protect human health and is a substitute of nitro-nail paint which is commonly used in market currently.