The invention discloses life-cycle anhydrous cooling liquid, comprising the following raw materials in parts: 30-35 parts of triethanolamine, 15-20 parts of triisopropanolamine, 10-12 parts of triethylamine, 5-11 parts of dichloromethane, 6-8 parts of triethylamine hydrochloride, 2-4 parts of ethyl acetate, 16-18 parts of ethyl alcohol, 12-20 parts of acetic acid, 5-6 parts of acetone, 6-8 parts of banana oil, 5-8 parts of polyethylene glycol, 2-3 parts of polyfluoroalkyl ethyl, 2-4 parts of 3-substituted sulfenyl-5-(2-hydroxyphenyl)-4H-1,2,4-triazole compound, 2-5 parts of oxalic acid, 3-6 parts of trichloroacetic acid, 3-5 parts of tartaric acid, 3-4 parts of azelaic acid, 2-3 parts of octanedioic acid, 3-5 parts of potassium sorbate, 3-6 parts of sodium glutamate, 2-3 parts of sodium carbonate, 2-3 parts of sodium hydroxide, 5-6 parts of silicone oil and 6-7 parts of Janus green. The life-cycle anhydrous cooling liquid does not contain water, so that the boiling point and the corrosion resistance of the cooling liquid and the balance temperature of an engine can be greatly improved, the engine can run at full load and high load, and vehicles can safely run in severe environments such as highlands, deserts and the like.