The invention discloses an enhanced nitrification process based on coupled demolding, and belongs to the technical field of sewage treatment. In the sewage nitrification process, under a condition ofkeeping a certain content of dissolved oxygen in a system, extrusion treatments are carried out on an elastic filler so as to generate different deformation degrees, in each extrusion treatment, deepextrusion and shallow extrusion are coupled; deep extrusion is carried out when the system load decreases, the effluent quality is close to an index value, or the system resistance exceeds a designedinflow water distribution pressure; and shallow extrusion is carried out when the system load is stable. Through the combination of deep extrusion and shallow extrusion, on one hand, demolding and redistribution of a bio-membrane filler can be realized, the mass transfer efficiency is improved, on the other hand, dissolved oxygen inside and outside the bio-membrane filler can be distributed more uniformly, through the synergistic effect of deep extrusion and shallow extrusion, the nitrification reaction is enhanced, the sewage treatment efficiency is improved, and the effluent quality is recovered.