The invention provides a submarine seamless line pipe above 415SPDF steel grade having large strain resistance. The submarine seamless line pipe comprises the following components, by weight, 0.05-0.11% of C, 0.20-0.40% of Si, 1.0-1.40% of Mn, less than or equal to 0.010% of P, less than or equal to 0.002% of S, 0.05-0.30% of Ni, 0.05-0.30% of Cr, 0.05-0.30% of Mo, 0.010-0.050% of Als, less than or equal to 0.010% of N, 0.010-0.050% of Nb, 0.03-0.08% of V, 0.05-0.25% of Cu, 0.008-0.030% of Ti, less than or equal to 0.020%of Pb, less than or equal to 0.020% of Sn, less than or equal to 0.030% of As, less than or equal to 0.015% of Sb, less than or equal to 0.015% of Bi, less than or equal to 0.0005% of B, less than or equal to 0.22% of carbon equivalent CEpcm, less than or equal to 0.39% of CEIIW, and less than or equal to 0.8% of a total amount of Ni, Mo, Cr and Cu that are added to Ni, Mo, Cr and Cu alloys. The submarine seamless line pipe has the benefits that after three times of pull-down circulation under 3% strain, the strength of the submarine seamless line pipe can be ensured to be greater than 415MPa, and ballistic work at minus 20 degrees of the submarine seamless line pipe can be ensured to be greater than 300J; the submarine seamless line pipe has less than or equal to 1.5% of crack sensitivity ratio (CSR), less than or equal to 5% of crack length ratio, and less than or equal to 3% of crack thickness ratio (CTR); and the submarine seamless line pipe does not break under 100% loading for 96h by an SSCB method.