The invention provides a proanthocyanidin oligosaccharide powder for endocrine regulation and a preparation method of the powder. The powder comprises the following components in parts by weight: 3-6parts of plant extracts with proanthocyanidins of greater than or equal to 95%, 70-90 parts of inulin, 10-20 parts of MCT powder, 1-2 parts of coffee powder, 0.5-1.5 parts of tea extracts with tea polyphenols of greater than or equal to 95%, and 0.5-1.5 parts of water-soluble pearl powder. According to the present invention, proanthocyanidins are combined with inulin, MCT powder, coffee powder, tea polyphenols and water-soluble pearl powder to obtain the proanthocyanidin oligosaccharide powder for endocrine regulation, and the powder not only has a good synergistic effect of regulating digestion and absorption, and increases the absorption utilization rate, but also is conducive to the antioxidant ability of proanthocyanidins, tea polyphenols, etc, in the body, improves the ability of removing free radicals in the body, has a more significant conditioning effect, is convenient for taking, and is effectively used in the powder health care products for treating facial skin diseases caused by pigmented dermatosis and skin glandular secretion disorders.