The invention discloses a synthetic method of N-(1H,1H,2H,2H-perfluorinated octyl) acrylamide. The method includes the steps that 1H,1H,2H,2H-perfluorinated hexyl ethyl iodide, sodium azide and organic solvent are mixed to react, water is added after the reaction is finished, the mixture is still standing and layered, and the organic layer is washed to obtain 1H,1H,2H,2H-perfluorinated octyl azide; under the action of Pd / C catalyst, hydrogen is used for hydrogenation reduction, and 1H,1H,2H,2H-perfluorinated octylamine is obtained through filtration and concentration; 1H,1H,2H,2H-perfluorinated octylamine, triethylamine and acryloyl chloride react in solvent at room temperature, after reaction is finished, the N-(1H,1H,2H,2H-perfluorinated octyl) acrylamide product is obtained through washing, concentration and reduced pressure distillation. The possibility of explosion in the production process is avoided, and the synthetic method has the advantages of being simple in process, safe in production, high in yield and easy to industrialize.