The invention discloses a preparation method of multi-effect care cream. The care cream is mainly prepared from Spanish cherry tree fruit grease oil, isododecane, octanoic acid/capric triglyceride, zinc oxide, phytosterol, dandelion extracts, safflower oil, allantoin, nicotinamide, lithospermum extracts, Chinese herbaceous peony extracts, plum-leaf crab seed oil, bisabolol, tocopherol/vitamin, menthol, menthyl lactate, butanediol, panthenol, beewax, microcrystalline wax, sorbitan isostearate, magnesium sulfate, decoyl hydroximic acid and water. The preparation method provided by the invention has the advantages that the skin sebum can be restored; nutrition can be given to the skin; the inflammation diminishing effect can also be achieved, and the like.