9 results about "Aldehyde synthesis" patented technology

The invention relates to the technical field of chemical synthesis, in particular to a preparation method of 1-benzyl alcohol-3-alkyl bicyclo [1.1. 1] pentane, which comprises the following steps: by taking aromatic aldehyde, [1.1. 1] propeller alkane and 4-alkyl substituted Hanss ester synthesized by aldehyde as initial raw materials and dichloroethane and the like as a solvent, carrying out a reaction under the protection of inert gas to obtain 1-benzyl alcohol-3-alkyl bicyclo [1.1. 1] pentane, and separating the 1-benzyl alcohol-3-alkyl bicyclo [1.1. 1] pentane from the 1-benzyl alcohol-3-alkyl bicyclo [1.1. 1] pentane. A three-component free radical coupling reaction is carried out under the illumination condition, and a 1-benzyl alcohol-3-alkyl bicyclo [1.1. 1] pentane product is synthesized in one step. The method has the advantages of mild reaction conditions, high reaction efficiency, low cost, simplicity and convenience in operation and the like, and a new method is provided for later structural modification of diaryl methanol drug molecules.

The application discloses a kind of synthesis aldehyde compound's method, it is related to green synthesis chemical field, the present application is synthesized by aldehyde synthesis device, the aldehyde compound synthesis device includes ionization source channel, gas sampling channel and mass spectrometer;First, ionization source channel is ionized into water radical cation cluster (H2O) 2 +· Ion;Then water radical cation cluster (H2O) 2 +· Ion and the positive alkane steam reacted by gas sampling channel output, produce alkane peroxide intermediate and aldehyde ion, finally using mass spectrometer to detect product, the present application provides a kind of green environmental protection synthesis aldehyde compound's method, can make a supplement to the existing synthesis aldehyde technical method, and reaction device is simple, need not catalyst, fast and efficient, high yield.

The application provides a propionaldehyde synthesis system and method, which comprises the following steps: 1) a raw material system comprising ethylene, carbon monoxide and hydrogen is reacted to obtain a gas phase product comprising propionaldehyde; 2) after the gas phase product is subjected to cooling treatment, a propionaldehyde liquid phase crude product and residual gas phase raw material are obtained, and the cooling treatment comprises internal cooling medium treatment and first external cooling medium treatment in sequence; 3) the propionaldehyde liquid phase crude product is subjected to stripping treatment by using synthesis gas raw material to obtain propionaldehyde and synthesis gas raw material after stripping; wherein the residual gas phase raw material and / or the synthesis gas raw material after stripping participates in the internal cooling medium treatment as an internal cooling medium. The propionaldehyde synthesis method can reduce the amount of first external cooling medium refrigeration water by subjecting the gas phase product to internal cooling medium treatment, thereby reducing energy consumption and production cost.

The invention belongs to the technical field of pharmaceutical chemistry, and discloses a diketopiperazine compound, a synthesis method, a pharmaceutical composition and application. The synthesis method comprises the following steps: synthesizing or providing imidazole formaldehyde C; synthesizing or providing an intermediate 2, 5-diketopiperazine derivative B; synthesizing or providing 3-substituted benzaldehyde A; 3-substituted benzaldehyde A and an intermediate 2, 5-diketopiperazine derivative B are subjected to Aldol condensation to obtain the diketopiperazine compound with the structure as shown in the formula (I). The invention also discloses application of the compound in preparation of medicines for preventing or treating cancers, especially application in preparation of medicines for treating lung cancers. The compound disclosed by the invention is novel in structure, part of the compound has excellent anti-tumor activity, all the compounds have excellent solubility, and the compound has a good development prospect.

The invention discloses a method for synthesizing indole based on 2-aminophenone and aldehyde, which comprises the following steps: by taking 2-aminophenone and aldehyde as reaction raw materials, mixing the 2-aminophenone and aldehyde with a reducing agent in a reductive catalytic system of cheap metal molybdenum, dissolving the mixture in an organic solvent, heating and stirring under an anaerobic condition, and separating and purifying to obtain the corresponding 2, 4-benzpyrole in one step. The invention discloses a 1, 3-disubstituted indole product. The method disclosed by the invention has the characteristics of simple and easily available raw materials, wide functional group compatibility and the like, can realize amplified-scale preparation of the 2, 3-disubstituted indole compound, has good production practicability, and has very high application value in the fields of organic synthesis, drug synthesis and the like.

The application discloses an olefin hydroformylation aldehyde synthesis production device and process, comprising the following steps: (1) the raw material enters the bubble reactor of the reaction section of the reaction extraction rectifying tower and mixes with the catalyst, and carbon monoxide and hydrogen are introduced to carry out the hydroformylation reaction under high pressure; (2) the reaction product is overflowed to the rectifying section to carry out separation; (3) the alkanes byproduct and the olefin raw material with similar boiling points are separated through the eccentric rotating disc extraction tower of the extraction section of the reaction extraction rectifying tower; (4) the light components on the tower top are separated through the rectifying section; (5) the heavy components in the tower kettle are separated through the dividing wall column, and the aldehyde product is obtained through purification. The application adopts a new type of ionic liquid catalyst, separates the olefin and the alkane in the reaction extraction rectifying tower, improves the raw material utilization rate, simultaneously reduces the waste of the catalyst and the discharge of the raw material waste liquid, and increases the reaction conversion rate and the yield.

A synthesis method of heliotropin relates to the technical field of heliotropin synthesis, and comprises the following steps: S1, uniformly mixing glyoxylic acid, glacial acetic acid and benzodioxole, then slowly dropwise adding concentrated sulfuric acid under a first temperature condition, reacting for a period of time, slowly dropwise adding nitric acid under a second temperature condition, reacting for a period of time, then adding hydrochloric acid, and reacting for a period of time to obtain a mixed solution; reaction liquid is obtained; s2, filtering the reaction liquid obtained in the step S1 to obtain a heliotropin crude product and filtrate; s3, recovering the filtrate obtained by filtering in S2, and washing, filtering and drying the heliotropin crude product obtained in S2 to obtain heliotropin; the heliotropin is prepared by a one-pot method, so that the synthesis steps are simplified, the whole synthesis method is simpler and more convenient to operate, the synthesis efficiency is improved, redundant wastewater is not generated, meanwhile, the recovery rate of filtrate can reach 95-99%, and the cost of raw materials is reduced.

The invention discloses a method for synthesizing cycloxaprid by using unilateral aldehyde, which comprises the following steps: by using 4-acetoxybutyraldehyde as an initial raw material, selectively protecting the aldehyde group of the 4-acetoxybutyraldehyde through an accurate pH value regulation strategy, oxidizing the alcoholic hydroxyl group at the other end into the aldehyde group under specific conditions, and reacting to obtain the cycloxaprid by using the unilateral aldehyde. And finally, carrying out cyclization reaction on the cycloxaprid and 2-chloro-5-((2-(nitromethylene) imidazoline-1-yl) methyl) pyridine in an acid environment, so as to prepare the cycloxaprid in one step. According to the invention, the raw material is further extended to cheap 1, 4-butanediol, and the key intermediate is prepared through selective protection and oxidation. According to the technology, separation of unstable intermediates is avoided through ingenious reaction time sequence control, high yield and high chemical purity are achieved, raw materials can be recycled, the technology has the outstanding advantages of being high in atom economy, low in cost, environmentally friendly and the like, and the problems that a traditional production technology is low in yield and difficult to scale are perfectly solved.

The application relates to a lauric aldehyde synthesis method and relates to the field of chemical synthesis, and comprises the following steps: under the action of a composite catalyst, lauryl alcohol is reacted with an oxidant in a solvent to obtain lauric aldehyde, and the pH of a reaction system is 7-10; wherein the composite catalyst comprises a metal halide and a TEMPO derivative; the TEMPO derivative is selected from one or more of 4-hydroxy-TEMPO and 4-methoxy-TEMPO; and the oxidant is a hypochlorite. The application solves the problems of high cost and difficulty in obtaining raw materials in the prior art, and has the advantages of mild catalytic reaction conditions, simple post-treatment steps, high reaction yield, high product purity, low production cost and suitability for industrial production.