46results about How to "Accurate detection means" patented technology

The invention discloses a method for oxidative desulfurization of fuel oil by adopting polyacid intercalation trihydroxymethyl hydrotalcite and ionic liquid extraction catalysis. According to the method, high-sulfur fuel oil is subjected to catalytic oxidation in a catalytic system with combined use of polyacid intercalation trihydroxymethyl hydrotalcite, ionic liquid and oxydol, an effect of deep desulfurization is achieved under a mild condition, and efficient and clean utilization of an energy source is realized. The trihydroxymethyl hydrotalcite is used as a carrier, and the catalytic performance of polyacid can be greatly improved by using the characteristics of large surface area and limited range space of the carrier; a polyacid intercalation hydrotalcite composite material of the type not only has functional characteristics of anionic clay and polyacid ions, but also has a practical significance for solving the problem of immobilization of heteropolyacid during industrial catalysis; and meanwhile, the intercalation hydrotalcite composite material has a meso-microporous structure, and is very suitable for selective catalytic reaction. Moreover, a catalyst and the ionic liquid cannot be degraded after multiple times of cyclic reaction, so that the method is a relatively successful desulfurization method.

The invention relates to a tumor stem cell marker CD133-targeting polypeptide and an application thereof. A general formula of the polypeptide is CX1X2X3X4X5X6X7X8LX9. The invention further relates to a DNA fragment encoding the polypeptide, an expression vector and host cell expressing the polypeptide, and a bivalent body, a multivalent body or a pharmaceutical composition formed by the polypeptide. The polypeptide is used for detecting and targeting the tumor stem cell, and is good in specificity and sensitivity, simple in preparation method, low in cost and high in practicability. The polypeptide is applied to near-infrared fluorescence imaging to carry out high-sensitivity and high-resolution monitoring and targeted therapy on the CD133 tumor stem cell in a skin transplatation tumor. Simple, fast, economical and accurate detection means can be provided for real-time monitoring of peripheral blood CD133 expression of a patient and the correlation of the CD133 tumor stem cell in tumor recurrence, metastasis, drug tolerance and prognosis, so that the therapeutic scheme is convenient to timely adjust and novel means can be provided for improving the prognosis of patients.

The invention relates to the technical fields of molecular biology and medicine, in particular to a polypeptide targeting PD-L1 and its application. The present invention provides a polypeptide targeting PD-L1, its general formula is NX 5 x 4 x 3 EX 2 x 1 g. The polypeptide of the present invention has high affinity and specificity to PD-L1, can specifically and efficiently target PD-L1 positive tumor cells, and can be used as a polypeptide molecular probe to detect the expression of PD-L1 in tumor cells, and to Real-time monitoring of the efficacy of immunotherapy and screening of patients suitable for immunotherapy; it can also be used as a targeting polypeptide for targeted therapy and imaging of tumors with high expression of PD‑L1, and has broad application prospects.