A four-effect vacuum energy-saving evaporative crystallization system for high-concentration saline wastewater comprises a material storage tank, a feeding pump, a plate heat exchanger, a single-effect heater, a single-effect evaporative crystallizer, a double-effect heater, a double-effect evaporative crystallizer, a triple-effect heater, a triple-effect evaporative crystallizer, a quadruple-effect evaporative crystallizer, a surface cooler, a slurry barrel, a centrifuge, a crystal collection tank, a mother liquid storage tank, and a mother liquid pump. The four-effect vacuum energy-saving evaporative crystallization system for high-concentration saline wastewater is characterized in that the material storage tank is sequentially connected to the feeding pump, the plate heat exchanger, the single-effect heater, the single-effect evaporative crystallizer, the double-effect heater, the double-effect evaporative crystallizer, the triple-effect heater, the triple-effect evaporative crystallizer, the quadruple-effect heater, the quadruple-effect evaporative crystallizer, the surface cooler, the slurry barrel, the centrifuge, the crystal collection tank, the mother liquid storage tank, and the mother liquid pump. The four-effect vacuum energy-saving evaporative crystallization system for high-concentration saline wastewater is low in comprehensive power consumption, and the quality of evaporative crystallization product industrial salt reaches the level 2 standard requirement of refined salt provided in the national industrial salt standard (GBT542-2003).