The invention belongs to the technical field of self-lubricating materials, and relates to a preparation method of a molybdenum disulfide-graphite oxide-nickel phosphorus-polytetrafluoroethylene composite material, and the method comprises the following steps: S1, performing plasma treatment on polytetrafluoroethylene powder, and after irradiation for 60-120 seconds, putting the polytetrafluoroethylene powder for standing for 15-30 minutes in air; S2, performing pretreatment on graphite powder, S3, performing sensitization and activation treatment on the polytetrafluoroethylene powder, to be more specific, after wetting of the polytetrafluoroethylene powder treated by plasma with absolute ethanol, respectively performing sensitization and activation on the polytetrafluoroethylene powder; S4, preparing graphite-nickel phosphorus-polytetrafluoroethylene composite powder, S5, preparing graphite oxide-nickel phosphorus-polytetrafluoroethylene composite material powder, and S6, preparing the molybdenum disulfide-graphite oxide-nickel phosphorus-polytetrafluoroethylene composite material, to be more specific, first, molybdenum disulfide-graphite oxide-nickel phosphorus-polytetrafluoroethylene composite material powder is prepared, and the molybdenum disulfide-graphite oxide-nickel phosphorus-polytetrafluoroethylene composite material powder is molded to obtain the wear resistant andantifriction molybdenum disulfide-graphite oxide-nickel phosphorus-polytetrafluoroethylene composite material.