The invention discloses a polypeptide derived from moon
jellyfish, and a preparation process and application thereof. The polypeptide is prepared according to the following steps: (1) taking fresh orfrozen moon
jellyfish, washing the moon
jellyfish with sea water or deionized water, putting the moon jellyfish into a reaction kettle, and adding a chelating agent and a
metal salt; (2) at 1-10 DEG C, starting stirring paddles to pulverize the moon jellyfish until no visible jelly-like particles in the mixture, and homogenizing the mixture; (3) filtering the mixture, retaining residues, and washing the residues with ionized water; (4) putting the washed residues into an
enzyme reaction vessel, adding deionized water and
protease, conducting a reaction at 35-60 DEG C for 2-10 h, conducting heating to 90-100 DEG C, keeping the temperature for 10-20 min, and conducting inactivation; (5) cooling the reaction products to 35-60 DEG C, adding an appropriate amount of a chelating agent
enzyme, conducting reaction for 2-10 h, then conducting heating to 90-100 DEG C, keeping the temperature for 10-20 min, and conducting inactivation; and (6) conducting cooling to
room temperature, adding a precipitant to the mixture, conducting stirring for 10-30 min, conducting filtering, and collecting the filtrate and conducting
drying to obtain a moon jellyfish polypeptide. The moon jellyfish polypeptide can be widely used in the fields of
cosmetics, health care products, and pharmaceuticals.