A high-temperature and high-pressure-resistant solvent-free heavy-duty anti-corrosion coating composition, including material A and material B, material A is obtained from a system comprising the following components: 40-60 parts of novolac epoxy resin, 5-10 parts of bisphenol F resin, and the reaction Type toughening agent 5-10 parts, reactive diluent 5-10 parts, thixotropic agent 1-3 parts, heat-resistant pigment 5-10 parts, additives 1-2 parts, filler 5-10 parts; material B is 20 ‑30 parts of curing agent, which is a mixture of modified fatty amine and modified phenalkamine. The high-temperature and high-pressure-resistant solvent-free heavy-duty anti-corrosion coating in the present invention is a solvent-free system, and the coating is environmentally friendly and green, and can be normally applied at 0-40°C, cured at room temperature, and does not need heating. After the coating is fully cured, it can achieve long-term anti-corrosion function under high-pressure, high-temperature, heavy-corrosion working conditions such as water-mixed pipelines and high-pressure gas-collecting pipelines, improve the use efficiency of pipelines, and improve the safety of transportation.