33results about How to "Mild conditions in the production process" patented technology

The invention discloses a synthetic method of 5-cholro-8-quinoline oxyacetic acid, and relates to the technical field of electrochemical organic synthesis. The synthetic method disclosed by the invention is used for solving the problems that the existing cloquitocet-mexyl production process is severe in environmental pollution, poor in selectivity and the like. The operating condition of the method is as follows: in a single-chamber electrolytic tank, platinum sheets are taken as negative and positive electrodes, 8-quinoline oxyacetic acid is taken as a raw material, and aqueous liquor of hydrochloric acid is taken as an electrolyte; 5-cholro-8-quinoline oxyacetic acid can be synthesized with high yield and high selectivity by adjusting the current strength. The method disclosed by the invention mainly has the advantages that chlorine is not directly used in production, so that the safety problem and environmental pollution problem caused by use of chlorine are avoided. In addition, the method provided by the invention is mild in condition of production process, simple to operate, high in product yield, few in byproduct and low in cost, and has greater practical value and social and economical values.

The invention relates to an enzymatic synthesis method of a chiral beta-hydroxyl ester compound. The chiral beta-hydroxyl ester compound is compounded as the formula (1). The enzymatic synthesis method comprises the following steps: carrying out a reaction on a compound i and a compound ii at the temperature of 0 DEG C to the room temperature under the condition of using pyridine as an acid binding agent, enabling the resultants to backflow in R2OH after the resultants are extracted and concentrated, recrystallizing the resultants to obtain the compound iii, adding the compound iii, chalcone reductase and cozymase into a phosphate buffer with pH vale of 6-8, and reacting for 2-24 hours at the temperature of 15-40 DEG C to obtain the chiral beta-hydroxyl ester compound provided by the invention. The enzymatic synthesis method provided by the invention is used for preparing a chiral beta-hydroxyl ester compound, and expensive chiral reagents are not needed. The enzymatic synthesis method provided by the invention has the advantages of mildness in production process conditions, easiness for obtaining raw materials, high conversion rate, low production cost and the like, which is suitable for large-scale industrial production.

The invention discloses a method for preparing albendazole with chloropropane in place of bromopropane, and belongs to the technical field of synthesis of imidazole compounds. The method comprises the following steps of firstly, sequentially adding carbendazol, sodium thiocyanate and glacial acetic acid into a reactor, performing uniform stirring, raising the temperature to 35 DEG C, slowly and dropwise adding a hydrogen peroxide solution under a stirring state, and performing a reaction so as to obtain solid 5-sulfhydryl benzimidazole-2-carbaminic acid methylester; preparing a chlorobenzene Grignard reagent by using 1,2-bromofume Grignard reagent; and then adding a phase transfer catalyst namely benzyl triethyl ammonium chloride to the solid 5-sulfhydryl benzimidazole-2-carbaminic acid methylester, slowly and dropwise adding a tetrahydrofuran solution of sodium hydride under the stirring state, performing a reaction for 30 minutes, beginning to slowly and dropwise drop the chlorobenzene Grignard reagent under the stirring condition, and performing a reaction so as to obtain an albendazole product. According to the method disclosed by the invention, the chloropropane is used for replacing the bromopropane which is relatively higher in price, so that not only is the investment cost of reaction raw materials reduced, but also the yield and the purity of the albendazole are guaranteed to be increased.

The invention relates to a preparation method of foam particles. The preparation method of the foam particles comprises the following steps: S1, a microwave sensitizer is embedded into an expandable base material in a mass ratio of the microwave sensitizer to expandable base material being 0.01-2:92.5-98, and preprocessed particles are obtained; S2, the preprocessed particles obtained in the step 1 are mixed with a foaming agent and a foaming penetration enhancer, the mixture is placed in a closed container and left to stand to enable the foaming agent to penetrate the preprocessed particles sufficiently, and a foamed pre-expanded body is obtained; S3, the foamed pre-expanded body obtained in the step 2 is subjected to microwave heating and subjected to surface cooling anti-sticking processing, foaming is performed, and the foam particles are obtained. The method can be applied to foaming of various polymer elastomers, the process is simple, and requirements for conditions are low. Various thermoplastic polyurethane foam particles prepared with the method have excellent performance.

The invention provides a burley tobacco extract applied to a heated-non-combustible cigarette and an application of the burley tobacco extract. With a composite biological material of burley tobacco stems and bagasse as an immobilized carrier, biological preparations, including a microbial aroma-producing strain and enzyme, are adsorbed; burley tobacco powder is incubated, hydrolyzed and fermented; and in combination with a continuous counter-current ultrasonic solvent extracting technology, the burley tobacco extract is prepared, and the burley tobacco extract can be combined with propylene glycol; intrinsic intense fragrance of natural tobacco is reserved; characteristic smell of burley tobacco is relieved and irritation is reduced; the burley tobacco has natural composite fragrance of fresh fruity aroma, smell of caramel, smell of being roasted and the like; the preparation method of gentle in process conditions, high in extracting rate and high in production efficiency; the burleytobacco extract is applied to a novel heated-non-combustible cigarette material; the burley tobacco extract is coordinate with cigarette fragrance and uniform in style, and the burley tobacco extractcan increase smoke concentration, enhance feeling of being satisfied and enrich cigarette aroma; and irritant smell of burley tobacco is obviously reduced, and taste is improved.