The present invention discloses a multifunctional honey Chinese prickly ash wine and preparation and use methods thereof. The multifunctional honey Chinese prickly ash wine is mainly characterized bycomprising raw materials of honey, Chinese prickly ash and edible baijiu, a mixture of saturated solutions of the honey and Chinese prickly ash in wine, divided into an oral administration type, an external use type and a simple type with volume ratios of honey wine to Chinese prickly ash wine at 2/1, 1/2 and 10%-90%, resepctively. The provided preparation method is easy to operate, preparation processes are clean and pollution-free, and the finished product is convenient to store for a long time and use. The health-care medicinal wine has remarkable effects of warming middle warmer and dispelling cold, removing dampness and moistening dryness, diminishing inflammation, relieving itching, relieving swelling and pains, etc., has special effects on solving problems of paronychia, tenosynovitis, scapulohumeral periarthritis, haemorrhoids, joint swelling and pains, sprain pains, waist and back ache and swelling pains, eczema, urticaria, pudendum damp itching, etc., and neurodermatitis, rheumatic arthritis, herpes zoster neuralgia and other neurological diseases, and is suitable for epidemic prevention of poultry and livestock.