A preparation method of vinyl chloride-vinyl acetate copolymer blended resin. Add vinyl chloride, vinyl acetate, initiator, sizing agent, pH stabilizer, dispersant, auxiliary dispersant and water into the polymerization kettle, react at a temperature of 40-70°C for 3-8 hours, and then add terminator , the aqueous suspension of vinyl chloride-vinyl acetate copolymer blended resin can be obtained, and then purified by conventional methods to remove unreacted vinyl chloride monomer and vinyl acetate monomer, centrifugal dehydration and drying to obtain the finished product . The invention is easy to operate and simple in equipment, and the prepared vinyl chloride-vinyl acetate resin has a compact particle structure, fine and uniform particles, concentrated distribution and low oil absorption rate, can greatly reduce the plasticizing temperature, and improve the storage stability of the plastisol, Improve the flow thixotropy of the paste. Can be widely used in artificial leather, floor leather, wallpaper and other adhesives, marine coatings, steel plate coatings, automotive sealants, anti-rust coatings, and anti-stone impact coatings for automotive chassis.