42results about How to "Reduce the risk of reactions" patented technology

The invention discloses a polymeric aluminum sulfate synthesis method and discloses a preparation method of a novel alkali-free liquid accelerator based on synthesis of polymeric aluminum sulfate. According to the alkali-free accelerator, an aluminum sulfate solution is neutralized by ammonia water, active aluminum hydroxide gel is prepared, active aluminum hydroxide is filtered, dried and ground into powder, then the aluminum sulfate solution is added, and the polymeric aluminum sulfate is prepared. The alkali-free accelerator comprises, in percentage, 45%-55% of the polymeric aluminum sulfate, 0%-5% of inorganic acid, 0%-2% of a stabilizer, 0%-2% of an organic early strength agent, 0%-2% of an organic tackifier and the balance of water. The cement setting time and the colloidal mortar strength of the accelerator can meet the requirement of first-class accelerators for JC477-2005 sprayed concrete under the condition of the lower mixing amount, and meanwhile, the accelerator is an alkali-free liquid accelerator and can effectively avoid adverse effects caused by excessively high alkali content. The cement types of the accelerator have good adaptability.

The invention provides a continuous production method for a vulcanization accelerator DPG. The method comprises the following steps that (1) diphenylthiourea, a catalyst, ammonium hydroxide and an organic solvent are mixed to obtain a reaction raw material mixture; (2) the reaction raw material mixture and an oxidizing agent are subjected to an oxidation reaction in a continuous flow reactor to obtain a reaction product; (3) the reaction product is post-treated to obtain the vulcanization accelerator DPG, wherein the organic solvent in step (1) can dissolve the diphenylthiourea and the vulcanization accelerator DPG. The method reduces the pressure in the reaction process, improves the utilization rate of the raw materials, stabilizes the product quality, greatly shortens the reaction timecompared with a conventional technology, improves the reaction yield, and effectively overcomes the disadvantage of traditional kettle type batch production.

The invention relates to a vecuronium bromide pharmaceutical composition for injection and a preparation method thereof. The vecuronium bromide pharmaceutical composition is characterized in that the pharmaceutical composition consists of vecuronium bromide, citric acid and disodium hydrogen phosphate. In the prescription of the vecuronium bromide pharmaceutical composition, amino acid, lactose, and the like are not used as excipients, so that a risk that the amino acid possibly reacts with the main drug is lowered, and safety risk caused by adding lactose is eliminated at the same time, and therefore, safety is better; and moreover, technical prejudice that product outline is kept by adding excipients such as mannitol, and the like in the prior art are overcome. The vecuronium bromide pharmaceutical composition disclosed by the invention is simple in prescription, lowers production cost to a certain extent, and is more suitable for industrial production.

The invention discloses a synthesis method of alkyl phosphinic acid and aluminium salt thereof under a normal-pressure mild condition. A hypophosphorous acid solution and alcohol are adopted as raw materials, by means of an organic solvent which has an azeotropy point with water, through in-situ reaction of olefin, the alkyl phosphinic acid is synthesized, after reaction is completed, the pH is adjusted, an aluminium salt solution is added, and alkyl aluminum hypophosphite precipitates as a white precipitate. According to the synthesis method of the alkyl phosphinic acid and the aluminium saltthereof under the normal-pressure mild condition, operation is simple and convenient, concentration of the hypophosphorous acid solution is avoided, energy consumption is reduced, and the efficiencyis improved; the alcohol not only can be used as the raw material for in-situ reaction of the olefin, but also can promote homogeneous system generation of the reaction, so that inconvenience of easyauto-agglutination brought by using acetic acid as a solvent and using olefin as an oligomer is eliminated; by using the solvent co-boiling with water, the purposes of solvent recovery and recycle areachieved, and it is easier to obtain the high-quality salt-forming product; the method is implemented under the normal-pressure mild condition, a security coefficient is high, the reaction risk is small, a synthesis technology is more energy-saving, environmentally friendly and efficient, and industrial production is easier to achieve.

The invention provides a retrievable hazardous waste rigid landfill system and an operation method. The retrievable hazardous waste rigid landfill system comprises a hazardous waste landfill reservoir area, a discharging channel, an overhauling interlayer, a portal crane, a steel-structured canopy and a personnel operation walkway plate. The hazardous waste landfill reservoir area is erected on the overhauling interlayer and composed of a plurality of landfill units. Each landfill unit comprises a reinforced concrete retaining wall and a bottom plate and is provided with a bottom plate anti-seepage system, a retaining wall anti-seepage system and a leachate collecting pipe, wherein pipe walking lines of the leachate collecting pipes are mainly located in the overhauling interlayer. The overhauling interlayer is an overhead layer and located below the hazardous waste landfill reservoir area. The portal crane is located above the landfill reservoir area. The steel-structured canopy is located on the upper portion of a crane. Personnel walkways are arranged on the periphery or/and in the landfill reservoir area. The retrievable hazardous waste rigid landfill system has more reliable safety, operable retrievable landfill is achieved, and management and maintenance are facilitated.

The invention relates to a preparation method and device of diiodosilane, and relates to the field of synthesis methods of semiconductor materials, the preparation method comprises the following steps: 1, mixing and dissolving iodine with at least one of chloroform, dichloromethane and dichloroethane according to a volume ratio of 1: (2-5); the phenylsilane is mixed with at least one of ethyl acetate, tert-butyl acetate and butyl acetate according to the mass ratio of 100: (1-5); pre-cooling the iodine solution and the phenylsilane solution at-40 to 0 DEG C; then pumping the mixture into a microchannel reactor, carrying out mixed reaction for 100-300 seconds in a low-temperature microchannel at-40-10 DEG C, and then introducing the mixture into a room-temperature microchannel at 20-30 DEG C to react for 100-400 seconds, so as to obtain a reaction mixture; and 2, carrying out vacuum rectification on the reaction mixture obtained in the step 1, and collecting the product with the fraction temperature of 35-40 DEG C under 20 +/-3 mmHg to obtain the high-purity diiodosilane. The diiodosilane is synthesized through the microchannel reactor, the original synthesis period can be shortened to be within 700 seconds, and the obtained mixture product is high in content and low in impurity metal ion content.

The invention discloses a cabozantinib preparation method. The target product cabozantinib is prepared by performing five-step reaction on diethyl malonate, 4-fluoroaniline, 4-chloro-6,7-dimethoxyquinoline, 4-aminophenol, 1,2-dibromoethane and the like used as raw materials. The preparation method is simple to operate and friendly to environment; the comprehensive yield is more than 50% and is obviously increased in comparison with the yield of 20% in the prior art; and the preparation method greatly lowers the existing medicine production cost, and is suitable for industrial large-scale production.

The invention relates to a preparation method of tetrafluoropropyl trifluoroethylene ether. The preparation method comprises the following main steps: in an alkaline environment, under the condition of heating, carrying out substitution and elimination on tetrafluoropropanol and 1,2-dibromo-1,1,2-trifluoroethane to obtain the tetrafluoropropyl trifluoroethylene ether. Compared with the existing reaction, the method provided by the invention has the advantages of simple reaction type, mild reaction conditions, strong operability, no use of organic solvents, environmental protection, fast reaction rate and high product yield, overcomes the difficulty of using metallic sodium and organic solvents in the prior art, reduces the reaction risk, and is suitable for industrial production.

The invention belongs to the field of building materials, and particularly relates to an accelerator as well as a preparation method and an application thereof. The accelerator is mainly prepared by mixing water and the following raw materials in parts by mass: 35-50 parts of aluminum salt, 1-3 parts of silicate, 3-10 parts of fluoride salt, 5-10 parts of a neutralizer and 5-10 parts of a stabilizer. The aluminum salt, the silicate, the fluoride salt, the neutralizer and the stabilizer are introduced into the accelerator, so that the accelerating effect is remarkable, and the stability of the accelerator can be obviously enhanced.

The invention discloses a method for efficiently preparing high-purity chloropinacolone, which comprises the following steps: adding quantitative pinacolone into a clean gasification kettle, and starting stirring; when the system is heated to 105-108 DEG C, pinacolone is gasified and enters the reactor, illumination is started, and chlorine is introduced into the reactor; the method comprises the following steps: reacting pinacolone with chlorine under an illumination condition to generate chloropinacolone; the outlet temperature of the reactor is ensured to be lower than 100 DEG C, pinacolone and chloropinacolone are liquefied and flow back into the gasification kettle, and hydrogen chloride gas generated by reaction can be discharged in time. According to the method disclosed by the invention, photocatalysis and gasification reaction are jointly applied to synthesis of the monochloropinacolone for the first time, and the obtained monochloropinacolone is high in yield, high in purity and low in byproduct content, and the quality of the monochloropinacolone is far higher than that of a product prepared by an existing process.

The invention discloses vaccine and a combination medicine for preventing tuberculosis, a method for preparing the vaccine and application, and belongs to the field of medicines for treating tuberculosis latent infection. By the aid of the vaccine with mycobacterium microbial compound adjuvants for preventing the tuberculosis, the problems of ineffectiveness or poor effects of existing subunit vaccine for treating tubercle bacillus latent infected population, diversified adjuvants, hypersensitivity and Koch reaction risks can be pertinently solved. The vaccine with mycobacterium microbial compound adjuvants for preventing the tuberculosis comprises Ag85b proteins, ESAT6-CFP10 proteins and mycobacterium vaccae thallus extract. The vaccine, the combination medicine, the method and the application have the advantages that the vaccine with the mycobacterium microbial compound adjuvants for preventing the tuberculosis is used for treating latent tuberculosis infection, and obvious effects can be realized; the vaccine only comprises a single type of adjuvants, and accordingly hypersensitivity and Koch reaction risks can be prevented.

The invention relates to a preparation method of pyridone derivatives and an intermediate thereof. Specifically, the present invention relates to a preparation method for preparing pyridone derivatives represented by formula (II) and pharmaceutically acceptable salts thereof from compounds represented by formula (6), intermediates in the preparation process and preparation methods thereof.