The invention discloses a synthesis method and application of a picoxystrobin intermediate, and the synthesis method of the picoxystrobin intermediate comprises the following steps: adding 200g of
acetone, 45-55g of (E)-4-hydroxymethylene-3-isochromone and 15g of
sodium hydroxide into a reaction flask, uniformly mixing, then dropwise adding 37-43g of
dimethyl sulfate, stirring, reacting, filtering, washing, and
drying to obtain the picoxystrobin intermediate. And after the
dimethyl sulfate is dropwise added, heating the reaction flask to 20-30 DEG C, carrying out a stirring reaction, filtering the
sodium methyl sulfate after the reaction is finished to obtain a filtrate, concentrating the filtrate, adding
methanol into the filtrate, crystallizing, filtering and
drying. According to the invention,
acetone is used as a
reaction system,
dimethyl sulfate is used for
methylation reaction, the reaction period is short, the
energy consumption is low, the reaction process is safe, the operation is simple, the production cost is low, and the obtained main by-product and the
solvent are almost in an insoluble state and are convenient to separate; the method takes
acetone as a
solvent, is simple to recover, low in
energy consumption, safe to operate, good in
environmental protection property and suitable for industrial production.