The invention discloses a long-time strong-adhesion
tissue repair patch and a preparation method thereof, and the preparation method comprises the following steps: adding an adhesion component, an anti-swelling component and alpha-
ketoglutaric acid into a colloidal
aqueous solution of a patch matrix material to obtain a precursor solution; and pouring the precursor solution into a patch mold, carrying out
ultraviolet curing, and
drying the obtained gel to obtain the patch. From the selection of materials and chemical bonds, physical and chemical bonds such as amido bonds, disulfide bonds and
catechol groups are combined, so that the
adhesion strength is improved, the adhesion duration is prolonged, and the
adhesive has excellent anti-swelling performance and mechanical performance, can effectively isolate external
saliva, food residues and the like when being applied to the
oral cavity, reduces infection of ulcer wounds, and has a good application prospect. The dental
ulcer healing is accelerated, and the method also has a relatively good application prospect in the field of
tissue repair.