A production method for a two-sided heterochromous self-cleaning jean fabric is characterized in that warp is ring spun combed cotton yarn with the yarn count of 21S, and the twist of the warp is controlled at 350-380 twists per meter; weft is fibrilia or bamboo fiber with natural antibacterial properties, and the yarn count of the weft is 24S; the warp has two colors, the weft is raw white, and a double-layer organization formed on the same basis is adopted, wherein the surface layer and the lining layer are both right twills with three up and one down, and the lining layer is connected with the surface layer through a down-to-up method; four binding places are formed in one woven circulation organization, wherein the organization arrangement mode of the surface weft and the lining warp is that the right twills are arranged with one up and three down, the arrangement rate of the surface warp to the lining warp is 1:1, and the arrangement rate of the surface weft to the lining weft is 1:1. According to the production method, the warp is subjected to spooling, beaming, dyeing, sizing, drying and drafting, and then the warp and the weft are jointly subjected to weaving, singeing, inclining, preshrinking, drying, inspection and packing. The two-sided heterochromous self-cleaning jean fabric can meet the demand that jeans wear is worn in a personal style, and the jeans wear has no peculiar smell after being worn for a long time.