The invention provides a method for processing tilapia fillet by combination of hot wind and microwave, which belongs to the technical field of aquatic product processing, and relates to a novel technique for processing the tilapia fillet by dehydration. The method is to uses fresh tilapia or frozen tilapia as a raw material to produce a product through selecting, pretreating, flaking, slicing, hot wind drying, microwave drying, cooling, packaging and storing. The novel method for processing the tilapia fillet by the combination of hot wind and microwave solves the problems of long time consumption, low efficiency, reduced product quality and the like for the prior hot wind dehydration, overcomes the cracking defect which often occurs in processing a high water content material by microwave, organically integrates two processing technologies of hot wind and microwave, realizes that safe moisture content can be achieved in a short period, improves the dehydrating efficiency and product quality, prominently improves the storage quality of the tilapia, and is beneficial to change the situations of single processed product of the tilapia and unprogressive processing level. The method is also suitable for processing dehydrated fillets, such as bighead, chub, grass carp and other fresh-water fish.