The invention discloses a
vitamin D3 purification method which comprises the following steps: a1, mixing organic amine, a first
organic solvent,
vitamin D3 oil and
aryl chloride to react, and then adding water to stop the reaction; a2, washing the product obtained in the step a1 with water, performing
drying and filtering, carrying out reduced pressure
distillation, performing dissolving, carryingout secondary reduced pressure
distillation, carrying out cooling and crystallizing; b1, dissolving
vitamin D3
methyl benzoate in
methanol, and dropwise adding a strong alkaline solution to perform reacting; b2, carrying out reduced pressure
distillation on the substance obtained in the step b1, then carrying out liquid separation, washing an organic phase with water, and carrying out
drying, filtering, carrying out secondary reduced pressure distillation, dissolving, cooling and recrystallizing; c1, dissolving the vitamin D3 crude product in a third
organic solvent, and then performing stirring for decolorization; and c2, filtering the product obtained in the step c1, carrying out reduced pressure distillation on the filtrate, and carrying out dissolving, cooling, recrystallizing, filtering, and
drying to obtain the vitamin D3. The vitamin D3 purified by the purification method disclosed by the invention has the advantages of higher purity, lower harmful
impurity content and higher stability.