The invention discloses an aqueous polyurethane antiseptic and waterproof coating with high cohesiveness. The coating comprises the following raw materials in parts by weight: 40-50 parts of polyurethane emulsion, 15-20 parts of pyridine ionic liquid, 5-8 parts of bamboo powder, 3-5 parts of nanometal, 18-22 parts of inorganic functional filling, 8-10 parts of vegetable oil, 1-3 parts of 2-naphthol, 1-3 parts of isopropyl myristate, 0.5-1 part of dibutyltin dilaurate, 1-3 parts of dimethyl sulfoxide, 3-5 parts of surfactant, 1-2 parts of coalescing agent and 60-80 parts of water. In the invention, pollution-free and environment-friendly ionic liquid is used as a cosolvent, the cohesiveness of the polyurethane emulsion can be greatly improved, and furthermore, nano-particles are uniformly dispersed in the coating, so that the difficult problem of aggregation of the nano-particles is solved. The coating provided in the invention has the advantages of strong cohesiveness, crack resistance, good waterproof performance, good corrosion resistance in severe environments such as acid, alkali, salt and oil, and obviously prolonged service life.