The invention discloses a large graphene stripping production method. The method comprises the following steps: S1, injecting graphite flakes and a stripping liquid into a kettle body with a stirrer, and starting a motor of the kettle body for stirring, wherein the stripping liquid comprises the components of 100 parts of water, 30-100 parts of an alcoholic solvent, 50-80 parts of polyacrylate or polyacrylate derivants, 1-30 parts of flaky metal powder and 0.5-5 parts of water soluble salt; S2, heating the kettle body, keeping the temperature in the kettle body to be 50-80 DEG C, keeping the pressure to be 1-3 atm, keeping the rotating speed of a stirring shaft to be 1000-2000 rpm and keeping the reaction time to be 3-6 h; S3, discharging an upper layer suspending liquid after the reaction stops, and performing still standing; S4, conveying the graphene suspending liquid to a centrifuge for centrifugation, taking a supernatant after centrifugation, and conducting vacuum filtration to obtain filter cake; S5, washing the filter cake, and conducting freeze drying. According to the method, equipment cannot be corroded, graphene cannot be damaged, and large graphene can be obtained.